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PMID: 7714909 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Frequencies of synonymous substitutions in mammals are gene-specific and correlated with frequencies of nonsynonymous substitutions.

Journal of molecular evolution ·Vol. 40 ·No. 1 ·1995-01-00 ·Pages 107-13

Mouchiroud D, Gautier C, Bernardi G

Abstract

The frequencies of synonymous substitutions of mammalian genes cover a much wider range than previously thought. We report here that the different frequencies found in homologous genes from a given mammalian pair are correlated with those in the same homologous genes from a different mammalian pair. This indicates that the frequencies of synonymous substitutions are gene-specific (as are the frequencies of nonsynonymous substitutions), or, in other words, that "fast" and "slow" genes in one mammal are fast and slow, respectively, in any other one. Moreover, the frequencies of synonymous substitutions are correlated with the frequencies of nonsynonymous substitution in the same genes.

MeSH Terms
Animals Biological Evolution Computer Simulation DNA Repair Gene Frequency Humans Mammals/genetics Models, Biological
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Mouchiroud D
Laboratoire de Biométrie, Génétique et Biologie des Populations, U.R.A. 243, Université Claude Bernard, Villeurbanne, France.
Gautier C
Bernardi G
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Article Info
Journal
Journal of molecular evolution
Abbr.
J Mol Evol
ISSN
0022-2844
DOI
10.1007/BF00166602
Published
1995-01-00
Pages
107-13
Language
English
Region
Germany
NLM ID
0360051
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00166602 View journal details
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