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PMID: 7809140 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Transcription of histone H4, H3, and H1 cell cycle genes: promoter factor HiNF-D contains CDC2, cyclin A, and an RB-related protein.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 91 ·No. 26 ·1994-12-20 ·Pages 12882-6

van Wijnen AJ, Aziz F, Graña X, De Luca A, Desai RK, Jaarsveld K, Last TJ, Soprano K, Giordano A, Lian JB

Abstract

Cell cycle-controlled human histone genes are coordinately expressed during S phase, and transcriptional regulation involves a series of trans-acting factors (HiNFs). The proliferation-specific factor HiNF-D interacts with multiple recognition motifs in histone H4, H3, and H1 promoters. Using gel shift immunoassays, we show that CDC2, cyclin A, and an RB-related protein are ubiquitous subunits of HiNF-D binding activity isolated from several cell types. HiNF-D levels in vivo are sensitive to okadaic acid and staurosporine, indicating that HiNF-D activity and/or assembly is influenced by phosphorylation status. Thus, HiNF-D appears to be a multicomponent phosphoprotein that participates in coordinate control of multiple histone H4, H3, and H1 genes during the cell cycle. The presence of cell cycle mediators in the HiNF-D complex suggests linkage between transcriptional control of histones, enzymes involved in DNA synthesis, and the onset of DNA replication during the G1/S phase transition.

MeSH Terms
Alkaloids/pharmacology Base Sequence CDC2 Protein Kinase/metabolism Cell Cycle Cyclins/metabolism DNA-Binding Proteins/chemistry,metabolism Ethers, Cyclic/pharmacology Gene Expression Regulation Histones/genetics Humans In Vitro Techniques Macromolecular Substances Molecular Sequence Data Okadaic Acid Oligodeoxyribonucleotides/chemistry Phosphorylation Promoter Regions, Genetic RNA, Messenger/genetics Retinoblastoma Protein/chemistry Staurosporine Transcription Factors/chemistry Transcription, Genetic Transcriptional Activation
Chemicals
Alkaloids Cyclins DNA-Binding Proteins Ethers, Cyclic Histones Macromolecular Substances Oligodeoxyribonucleotides RNA, Messenger Retinoblastoma Protein Transcription Factors Okadaic Acid CDC2 Protein Kinase Staurosporine
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
van Wijnen A J
Department of Cell Biology, University of Massachusetts Medical School and Cancer Center, Worcester 01655.
Aziz F
Graña X
De Luca A
Desai R K
Jaarsveld K
Last T J
Soprano K
Giordano A
Lian J B
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.91.26.12882
Published
1994-12-20
Pages
12882-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC45544
Subset
IM
Grants
NIAMS NIH HHS · AR39588 · United States
NIAMS NIH HHS · AR42262 · United States
NIGMS NIH HHS · GM32010 · United States
External Links
PubMed source DOI: 10.1073/pnas.91.26.12882 PMC Full Text View journal details
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