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PMID: 2006193 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Involvement of the cell cycle-regulated nuclear factor HiNF-D in cell growth control of a human H4 histone gene during hepatic development in transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 88 ·No. 6 ·1991-03-15 ·Pages 2573-7

van Wijnen AJ, Choi TK, Owen TA, Wright KL, Lian JB, Jaenisch R, Stein JL, Stein GS

Abstract

Regulation of the cell cycle-controlled histone gene promoter factor HiNF-D was examined in vivo. Proliferative activity was measured by DNA replication-dependent histone mRNA levels, and HiNF-D binding activity was found to correlate with cell proliferation in most tissues. Furthermore, HiNF-D is down-regulated during hepatic development, reflecting the onset of differentiation and quiescence. The contribution of transcription to histone gene expression was directly addressed in transgenic mice by using a set of fusion constructs containing a human H4 histone gene promoter linked to three different genes. Transgene expression in both fetal and adult mice paralleled endogenous mouse histone mRNA levels in most tissues, consistent with this promoter conferring developmental, cell growth-related transcriptional regulation. Our results suggest that HiNF-D is stringently regulated in vivo in relation to cell growth and support a primary role for HiNF-D in the proliferation-specific expression of H4 histone genes in the intact animal. Further, the data presented here provide an example in which apparent tissue specificity of gene expression reflects the proliferative state of various tissues and demonstrate that multiple levels of histone gene regulation are operative in vivo.

MeSH Terms
Aging Animals Brain/metabolism Cell Cycle Cell Division Cells, Cultured DNA Replication Histones/genetics Humans Liver/cytology,growth & development,metabolism Mice Mice, Transgenic Nuclear Proteins/metabolism Plasmids RNA, Messenger/genetics Transcription, Genetic
Chemicals
Histones Nuclear Proteins RNA, Messenger
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
van Wijnen A J
Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655.
Choi T K
Owen T A
Wright K L
Lian J B
Jaenisch R
Stein J L
Stein G S
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.88.6.2573
Published
1991-03-15
Pages
2573-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC51275
Subset
IM
Grants
NIGMS NIH HHS · GM32010 · United States
NCI NIH HHS · R35-CA44339 · United States
External Links
PubMed source DOI: 10.1073/pnas.88.6.2573 PMC Full Text View journal details
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