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PMID: 786889 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Variability of protection in inbred mice induced by a ribosomal vaccine prepared from Salmonella typhimurium.

Infection and immunity ·Vol. 14 ·No. 3 ·1976-09-00 ·Pages 652-9

Misfeldt ML, Johnson W

Abstract

Ribosomal vaccines prepared from Salmonella typhimurium were effective immunogens in A/J inbred mice and C3H/HeTex, inbred mice. However, ribosomal vaccines were not protective in C57BL/6J inbred mice. A/J mice were protected against lethal challenge by attenuated S. typhimurium live-cell, ribosomal, phenol, and heat-killed vaccines. C3H/HeTex mice were protected by live-cell, ribosomal, and phenol vaccines but not the heat-killed vaccine. Only the live-cell vaccine gave significant protection in the C57BL/6J inbred mice. A comparison of the kinetics of infection in sham-immunized mice and mice immunized with ribosomes showed that ribosome preparations elicited protection against Salmonella infection in mice inherently sensitive and resistant to Salmonella.

MeSH Terms
Animals Bacterial Vaccines/administration & dosage Kinetics Male Mice Mice, Inbred Strains Ribosomes/immunology Salmonella Infections, Animal/prevention & control Salmonella typhimurium/immunology Species Specificity Vaccination
Chemicals
Bacterial Vaccines
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Misfeldt M L
Johnson W
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45 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.14.3.652-659.1976
Published
1976-09-00
Pages
652-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC420936
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.14.3.652-659.1976 PMC Full Text View journal details
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