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PMID: 7878045 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The murine N-ras gene is not essential for growth and development.

Umanoff H, Edelmann W, Pellicer A, Kucherlapati R

Abstract

The mammalian ras gene family encodes key cell-signaling, cell growth-related proteins that have been highly conserved in species from yeast to man. Specific point mutations in the ras genes are associated with various mammalian tumors. To understand the developmental role of the N-ras protooncogene in the mouse, we have disrupted its gene function by homologous recombination in embryonic stem cells. Mice derived from these cells that are homozygous for the N-ras mutation do not produce any detectable N-Ras protein and are morphologically and histologically indistinguishable from their heterozygous and wild-type siblings. Since N-ras is expressed at high levels in hematopoietic cells, we examined different populations of cells in peripheral blood and found no differences between mutant and normal animals. Our results show that N-ras gene function is dispensable for normal mouse development, growth, and fertility.

Related Genes
MeSH Terms
Animals Base Sequence Gene Expression Regulation, Developmental Genes, ras Heterozygote Homozygote Mice Mice, Knockout Molecular Sequence Data Oligodeoxyribonucleotides/chemistry Proto-Oncogene Proteins p21(ras)/physiology Restriction Mapping
Chemicals
Oligodeoxyribonucleotides Proto-Oncogene Proteins p21(ras)
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Umanoff H
Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461.
Edelmann W
Pellicer A
Kucherlapati R
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
Published
1995-02-28
Pages
1709-13
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC42589
Subset
IM
Grants
NCI NIH HHS · CA 13330 · United States
NHGRI NIH HHS · HG00380 · United States
NINDS NIH HHS · T32NS07183 · United States
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