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PMID: 8031061 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Putative anticryptosporidial agents tested with an immunodeficient mouse model.

Antimicrobial agents and chemotherapy ·Vol. 38 ·No. 4 ·1994-04-00 ·Pages 865-7

Leitch GJ, He Q

Abstract

Lasalocid, sinefungin, and dehydroepiandrosterone were tested for anticryptosporidial activity with an immunodeficient mouse model at doses that have been reported effective when tested with immunosuppressed rodent models. Small but significant reductions in oocyst excretion were only observed under some conditions with lasalocid and dehydroepiandrosterone, but sinefungin had no effect.

MeSH Terms
Adenosine/analogs & derivatives,therapeutic use Animals Antiprotozoal Agents/therapeutic use Coccidiostats/therapeutic use Cryptosporidiosis/drug therapy,parasitology Cryptosporidium parvum/drug effects Dehydroepiandrosterone/therapeutic use Immunologic Deficiency Syndromes/parasitology Lasalocid/therapeutic use Male Mice Mice, Nude Splenectomy
Chemicals
Antiprotozoal Agents Coccidiostats Dehydroepiandrosterone Adenosine sinefungin Lasalocid
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Leitch G J
Department of Physiology, Morehouse School of Medicine, Atlanta, Georgia 30310.
He Q
References (19)
19 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.38.4.865
Published
1994-04-00
Pages
865-7
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC284557
Subset
IM
Grants
NCRR NIH HHS · RR03034 · United States
External Links
PubMed source DOI: 10.1128/AAC.38.4.865 PMC Full Text View journal details
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