Home LiteratureArticle Details
PMID: 8494386 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Curative and preventive anticryptosporidium activities of sinefungin in an immunosuppressed adult rat model.

Antimicrobial agents and chemotherapy ·Vol. 37 ·No. 4 ·1993-04-00 ·Pages 889-92

Brasseur P, Lemeteil D, Ballet JJ

Abstract

An immunosuppressed rat model was used to investigate the anti-Cryptosporidium parvum activity of sinefungin. In infected animals, oral sinefungin therapy resulted in a dose-related suppression of oocyst shedding, which correlated with oocyst disappearance from ileal sections. When administered prior to or on the day of oocyst challenge, sinefungin successfully prevented infection. These data suggest that sinefungin could be considered as a candidate molecule in the treatment of human cryptosporidiosis, considered to be the most significant enteric opportunistic infection in AIDS.

MeSH Terms
Adenosine/analogs & derivatives,therapeutic use Animals Antiprotozoal Agents/therapeutic use Cryptosporidiosis/drug therapy,parasitology,prevention & control Cryptosporidium parvum Dose-Response Relationship, Drug Feces/parasitology Immunosuppression Therapy Rats Rats, Sprague-Dawley
Chemicals
Antiprotozoal Agents Adenosine sinefungin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Brasseur P
Department of Parasitology, Hôpital Charles Nicolle, Rouen, France.
Lemeteil D
Ballet J J
References (23)
23 references, click to expand
  1. Cryptosporidiosis of man and calf: a case report and results of experimental infections in mice and rats.
    Am J Trop Med Hyg. 1982 Mar;31(2):226-9 PMID: 7072885
  2. Inhibitory activity of sinefungin and SIBA (5'-deoxy-5'-S-isobutylthio-adenosine) on the growth of promastigotes and amastigotes of different species of Leishmania.
    FEBS Lett. 1980 Dec 1;121(2):287-91 PMID: 6970144
  3. [A simple technic for the demonstration of cryptosporidia in feces].
    Zentralbl Veterinarmed B. 1982 May;29(4):324-7 PMID: 6181632
  4. Antitrypanosomal activity of sinefungin.
    Am J Trop Med Hyg. 1983 Jan;32(1):31-3 PMID: 6130709
  5. Amoebicidal activity of the antifungal antibiotic sinefungin against Entamoeba histolytica.
    Trans R Soc Trop Med Hyg. 1984;78(6):837-8 PMID: 6099924
  6. [Cryptosporidiosis in immunocompetent children].
    Presse Med. 1987 Feb 7;16(4):177 PMID: 2950456
  7. Chemotherapeutic effect of arprinocid in experimental cryptosporidiosis.
    J Parasitol. 1987 Jun;73(3):663-6 PMID: 3598815
  8. Antitoxoplasmosis properties of sinefungin in mice.
    C R Acad Sci III. 1988;306(3):109-13 PMID: 3126990
  9. Rat model for human cryptosporidiosis.
    J Clin Microbiol. 1988 May;26(5):1037-9 PMID: 3384895
  10. Anticryptosporidial activity of sulfadimethoxine.
    Antimicrob Agents Chemother. 1988 Dec;32(12):1907-8 PMID: 3245702
  11. Cessation of Cryptosporidium-associated diarrhea in an acquired immunodeficiency syndrome patient after treatment with hyperimmune bovine colostrum.
    Gastroenterology. 1990 Feb;98(2):486-9 PMID: 2295405
  12. New mouse models for chronic Cryptosporidium infection in immunodeficient hosts.
    Infect Immun. 1990 Apr;58(4):961-9 PMID: 2108092
  13. Effect of sinefungin on macromolecular biosynthesis and cell cycle of Plasmodium falciparum.
    Trop Med Parasitol. 1990 Sep;41(3):273-8 PMID: 2255844
  14. Asexual development of Cryptosporidium parvum within a differentiated human enterocyte cell line.
    Infect Immun. 1991 Jan;59(1):234-9 PMID: 1987037
  15. Cryptosporidiosis.
    Clin Microbiol Rev. 1991 Jul;4(3):325-58 PMID: 1889046
  16. Synthesis and biological activity of sinefungin analogues.
    J Med Chem. 1991 Sep;34(9):2798-803 PMID: 1895298
  17. Total synthesis of uracil analogues of sinefungin.
    J Med Chem. 1992 Jan;35(1):63-7 PMID: 1732534
  18. Characterization of anti-Cryptosporidium IgA antibodies in sera from immunocompetent individuals and HIV-infected patients.
    J Protozool. 1991 Nov-Dec;38(6):179S-180S PMID: 1818157
  19. Anti-cryptosporidial drug activity screened with an immunosuppressed rat model.
    J Protozool. 1991 Nov-Dec;38(6):230S-231S PMID: 1818183
  20. Chemotherapeutic effect of azithromycin and lasalocid on Cryptosporidium infection in mice.
    J Protozool. 1991 Nov-Dec;38(6):232S-233S PMID: 1667931
  21. A9145, a new adenine-containing antifungal antibiotic. II. Biological activity.
    J Antibiot (Tokyo). 1973 Aug;26(8):466-70 PMID: 4600794
  22. Plasmodium falciparum: antimalarial activity in culture of sinefungin and other methylation inhibitors.
    Exp Parasitol. 1980 Aug;50(1):83-9 PMID: 6993216
  23. The effect of adenosine analogues on the in vitro growth of Trypanosoma cruzi.
    Trans R Soc Trop Med Hyg. 1982;76(3):285-7 PMID: 7051450
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.37.4.889
Published
1993-04-00
Pages
889-92
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC187800
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.37.4.889 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2