Follicular origin of epidermal papillomas in v-Ha-ras transgenic TG.AC mouse skin.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 91 ·No. 16 ·1994-08-02 ·Pages 7822-6

Hansen LA, Tennant RW

Abstract

A follicular origin for some skin tumors has been hypothesized in both humans and animal models. Because of its rapid and sensitive response to tumor promoter treatment, a v-Ha-ras transgenic (TG.AC) mouse line was used to determine the origins of epidermal papillomas. Using histological studies and transgene expression as a marker for papilloma development, we determined that pedunculated papillomas arose from focal hyperplasias of the permanent portion of the follicular epithelium in phorbol 12-myristate 13-acetate-treated TG.AC mouse skin. Damage to the hair follicle by depilation was also sufficient to induce papillomas that were histologically indistinguishable from those produced by chemical exposure. Identification of the cellular origins of papillomas in this transgenic mouse model will allow for an analysis of the role of the hair follicle and hair cycle-associated signaling in tumor development.

MeSH Terms

Animals Female Genes, ras/genetics Hair Diseases/pathology In Situ Hybridization Mice Mice, Transgenic Papilloma/etiology RNA, Messenger/isolation & purification Skin/injuries,pathology Tetradecanoylphorbol Acetate/pharmacology

Chemicals

RNA, Messenger Tetradecanoylphorbol Acetate

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Hansen L A

Laboratory of Environmental Carcinogenesis and Mutagenesis, National Institute for Environmental Health Sciences, Research Triangle Park, NC 27709.

Tennant R W

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.91.16.7822

Published

1994-08-02

Pages

7822-6

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC44494

Subset

External Links

PubMed source DOI: 10.1073/pnas.91.16.7822 PMC Full Text View journal details

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Follicular origin of epidermal papillomas in v-Ha-ras transgenic TG.AC mouse skin.

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