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PMID: 8143343 Published · ppublish English Journal Article Review

Signal transduction by integrins and its role in the regulation of tumor growth.

Cancer metastasis reviews ·Vol. 13 ·No. 1 ·1994-03-00 ·Pages 25-30

Juliano R

Abstract

It has become clear that integrins have effects on tumorigenesis that are in addition to their role in mediating cell adhesion during invasive and metastatic processes. Integrins can transduce signals from the extracellular matrix to cell interior, via tyrosine kinases, and possibly by other mechanisms as well. These integrin mediated signals contribute to control of gene expression, to regulation of anchorage-dependence, to cell cycle transit, and to the control of tumor growth.

MeSH Terms
Animals Cell Division Gene Expression Humans Integrins/biosynthesis,physiology Neoplasms/pathology,physiopathology Signal Transduction Transcription, Genetic
Chemicals
Integrins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Juliano R
Dept. of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill 27599.
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51 references, click to expand
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Article Info
Journal
Cancer metastasis reviews
Abbr.
Cancer Metastasis Rev
ISSN
0167-7659
DOI
10.1007/BF00690416
Published
1994-03-00
Pages
25-30
Language
English
Region
Netherlands
NLM ID
8605731
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00690416 View journal details
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