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PMID: 8151797 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Feline immunodeficiency virus can be experimentally transmitted via milk during acute maternal infection.

Journal of virology ·Vol. 68 ·No. 5 ·1994-05-00 ·Pages 3380-5

Sellon RK, Jordan HL, Kennedy-Stoskopf S, Tompkins MB, Tompkins WA

Abstract

Postnatal transmission of feline immunodeficiency virus (FIV) in neonates nursed by acutely infected mothers and infection resulting from oral inoculation of kittens with FIV were evaluated. Ten of 16 kittens nursed by four queens with FIV infection established immediately postpartum developed FIV infection. Five of 11 neonates orally administered cell-free FIV culture supernatant developed FIV infection. Kittens that developed FIV infection had greater proportions of CD4+ and Pan-T+ lymphocytes at birth than negative kittens. Infectious virus was recovered from the milk of acutely infected mothers. We conclude that FIV may be experimentally transmitted via milk from queens with acute infections and that oral administration of FIV to neonatal kittens results in infection.

MeSH Terms
Animals Animals, Newborn/immunology,microbiology Animals, Suckling/immunology,microbiology Cats Humans Immunodeficiency Virus, Feline/pathogenicity Lentivirus Infections/immunology,transmission Milk/microbiology T-Lymphocyte Subsets
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Sellon R K
Department of Microbiology, Pathology, and Parasitology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
Jordan H L
Kennedy-Stoskopf S
Tompkins M B
Tompkins W A
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.68.5.3380-3385.1994
Published
1994-05-00
Pages
3380-5
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC236830
Subset
IM
Grants
NIAID NIH HHS · 1 RO1 AI32310 · United States
External Links
PubMed source DOI: 10.1128/JVI.68.5.3380-3385.1994 PMC Full Text View journal details
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