Home LiteratureArticle Details
PMID: 2762293 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Nucleotide sequence and genomic organization of feline immunodeficiency virus.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 86 ·No. 15 ·1989-08-00 ·Pages 5743-7

Talbott RL, Sparger EE, Lovelace KM, Fitch WM, Pedersen NC, Luciw PA, Elder JH

Abstract

An infectious molecular clone of the Petaluma strain of feline immunodeficiency virus (FIV) was isolated from a recombinant bacteriophage library containing genomic DNA prepared from FIV-infected Crandall feline kidney (CRFK) cells. The integrated provirus has a total length of 9472 base pairs. Three long open reading frames corresponding to GAG, POL, and ENV gene coding frames are evident. In addition, an open reading frame overlaps the 3' end of POL, in the region that encodes viral infectivity factor in the primate viruses. Several short open reading frames are present in the intergenic region between POL and ENV and within ENV, which may serve as exons for production of TAT and REV equivalents in FIV. Alignment of the predicted amino acid sequences of the FIV proteins with those of other lentiviruses indicates that FIV did not arise recently from any other characterized lentivirus.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Cats Cell Line DNA, Viral/genetics Genes, Viral Molecular Sequence Data Phylogeny RNA, Viral/genetics Retroviridae/genetics Transfection Viral Envelope Proteins/genetics
Chemicals
DNA, Viral RNA, Viral Viral Envelope Proteins
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Talbott R L
Department of Molecular Biology, Research Foundation of Scripps Clinic, La Jolla, CA 92037.
Sparger E E
Lovelace K M
Fitch W M
Pedersen N C
Luciw P A
Elder J H
References (30)
30 references, click to expand
  1. Nucleotide sequence of three isoaccepting lysine tRNAs from rabbit liver and SV40-transformed mouse fibroblasts.
    Eur J Biochem. 1979 Jun;97(1):305-18 PMID: 225173
  2. DNA sequencing with chain-terminating inhibitors.
    Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 PMID: 271968
  3. "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.
    Anal Biochem. 1984 Feb;137(1):266-7 PMID: 6329026
  4. Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2).
    Science. 1985 Feb 1;227(4686):484-92 PMID: 2578227
  5. Characterization of a cDNA clone encoding the visna virus transactivating protein.
    Proc Natl Acad Sci U S A. 1989 Jan;86(2):414-8 PMID: 2536163
  6. Epidemiologic and clinical aspects of feline immunodeficiency virus infection in cats from the continental United States and Canada and possible mode of transmission.
    J Am Vet Med Assoc. 1989 Jan 15;194(2):213-20 PMID: 2537269
  7. Feline immunodeficiency virus infection in cats of Japan.
    J Am Vet Med Assoc. 1989 Jan 15;194(2):221-5 PMID: 2537270
  8. Feline immunodeficiency virus infection.
    Vet Immunol Immunopathol. 1989 May;21(1):111-29 PMID: 2549690
  9. Nucleotide sequence of the AIDS virus, LAV.
    Cell. 1985 Jan;40(1):9-17 PMID: 2981635
  10. Complete nucleotide sequence of the AIDS virus, HTLV-III.
    Nature. 1985 Jan 24-30;313(6000):277-84 PMID: 2578615
  11. Nucleotide sequence evidence for relationship of AIDS retrovirus to lentiviruses.
    Nature. 1985 Sep 26-Oct 2;317(6035):366-8 PMID: 2995822
  12. Multiple nuclear factors interact with the immunoglobulin enhancer sequences.
    Cell. 1986 Aug 29;46(5):705-16 PMID: 3091258
  13. Structural characterization of reverse transcriptase and endonuclease polypeptides of the acquired immunodeficiency syndrome retrovirus.
    J Virol. 1986 Nov;60(2):771-5 PMID: 2430111
  14. Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome.
    Science. 1987 Feb 13;235(4790):790-3 PMID: 3643650
  15. Genome organization and transactivation of the human immunodeficiency virus type 2.
    Nature. 1987 Apr 16-22;326(6114):662-9 PMID: 3031510
  16. Nucleotide sequence analysis of equine infectious anemia virus proviral DNA.
    Virology. 1987 Jun;158(2):300-12 PMID: 3035786
  17. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.
    Anal Biochem. 1987 Apr;162(1):156-9 PMID: 2440339
  18. Sequence of simian immunodeficiency virus from macaque and its relationship to other human and simian retroviruses.
    Nature. 1987 Aug 6-12;328(6130):543-7 PMID: 3649576
  19. The visna virus genome: evidence for a hypervariable site in the env gene and sequence homology among lentivirus envelope proteins.
    J Virol. 1987 Dec;61(12):4046-54 PMID: 2824836
  20. Characterization of ribosomal frameshifting in HIV-1 gag-pol expression.
    Nature. 1988 Jan 21;331(6153):280-3 PMID: 2447506
  21. Human immunodeficiency virus protease expressed in Escherichia coli exhibits autoprocessing and specific maturation of the gag precursor.
    Proc Natl Acad Sci U S A. 1987 Dec;84(24):8903-6 PMID: 3321060
  22. Sequence of simian immunodeficiency virus from African green monkey, a new member of the HIV/SIV group.
    Nature. 1988 Jun 2;333(6172):457-61 PMID: 3374586
  23. EIAV genomic organization: further characterization by sequencing of purified glycoproteins and cDNA.
    Virology. 1988 Aug;165(2):601-5 PMID: 2841805
  24. Pathogenesis of experimentally induced feline immunodeficiency virus infection in cats.
    Am J Vet Res. 1988 Aug;49(8):1246-58 PMID: 2459996
  25. Signals for ribosomal frameshifting in the Rous sarcoma virus gag-pol region.
    Cell. 1988 Nov 4;55(3):447-58 PMID: 2846182
  26. Fatty acylation of proteins.
    Annu Rev Cell Biol. 1988;4:611-47 PMID: 3058168
  27. Evolutionary trees with minimum nucleotide replacements from amino acid sequences.
    J Mol Evol. 1974;3(4):263-78 PMID: 4413342
  28. Sequence at the 3' end of globin mRNA shows homology with immunoglobulin light chain mRNA.
    Nature. 1974 Nov 29;252(5482):359-62 PMID: 4139664
  29. A general method for isolation of high molecular weight DNA from eukaryotes.
    Nucleic Acids Res. 1976 Sep;3(9):2303-8 PMID: 987581
  30. Regulation of simian virus 40 transcription: sensitive analysis of the RNA species present early in infections by virus or viral DNA.
    J Virol. 1979 Aug;31(2):360-9 PMID: 225559
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.86.15.5743
Published
1989-08-00
Pages
5743-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC297706
Subset
IM
Grants
NIAID NIH HHS · R01-AI25802 · United States
NIAID NIH HHS · R01-AI25825 · United States
Databases
GENBANK
M25729
External Links
PubMed source DOI: 10.1073/pnas.86.15.5743 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2