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PMID: 815248 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Evolution and utility of a Pseudomonas aeruginosa drug resistance factor.

Journal of bacteriology ·Vol. 125 ·No. 3 ·1976-03-00 ·Pages 837-44

Olsen RH, Hansen J

Abstract

We describe the addition to the Pseudomonas aeruginosa sex factor, FP2, of carbenicillin resistance encoded by the RP1 plasmid. This occurred in a step-wise manner as detected by variations in the characteristics of the FP2-RP1 plasmid aggregate. The addition of the carbenicillin resistance marker to FP2 facilitates estimates of FP2 transfer. Transfer frequencies for the presumed cointegrate plasmid, using carbenicillin selection, approached 10(-1) per donor bacterium. The chromosomal mobilization properties of the derived plasmid, designated pR0271, resembled those of the progenitor plasmid FP2. Plasmid pR0271 was also observed to mobilize a nontransmissible drug resistance plasmid sharing genetic homology at frequencies corresponding to those observed for chromosomal markers proximal to the origin of transfer.

MeSH Terms
Anti-Bacterial Agents/pharmacology Carbenicillin/pharmacology Chromosomes, Bacterial Conjugation, Genetic F Factor Pseudomonas aeruginosa/drug effects R Factors Transduction, Genetic
Chemicals
Anti-Bacterial Agents Carbenicillin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Olsen R H
Hansen J
References (17)
17 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.125.3.837-844.1976
Published
1976-03-00
Pages
837-44
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC236156
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.125.3.837-844.1976 PMC Full Text View journal details
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