Electron microscopic study on the interaction between normal guinea pig peritoneal macrophages and Coxiella burnetii.

Infection and immunity ·Vol. 14 ·No. 4 ·1976-10-00 ·Pages 1087-96

Kishimoto RA, Veltri BJ, Canonico PG, Shirey FG, Walker JS

Abstract

An electron microscopic study was conducted to explore the interaction between normal guinea pig peritoneal macrophages and phase I and II Coxeilla burnetii previously treated with either normal or immune serum. A comparison was made on the efficiency of phagocytosis and subsequent killing of rickettsiae by macrophages. Both phases of rickettsiae previously treated with normal serum multiplied within phagosomes after phagocytosis with resultant destruction of macrophages. In contrast, suspending rickettsiae in immune serum rendered them more susceptible to phagocytosis and potentiated their destruction within macrophages.

MeSH Terms

Animals Coxiella/ultrastructure Guinea Pigs Lysosomes/enzymology Macrophages/microbiology,ultrastructure Microscopy, Electron Phagocytosis Rickettsia typhi/ultrastructure

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Kishimoto R A

Veltri B J

Canonico P G

Shirey F G

Walker J S

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29 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.14.4.1087-1096.1976

Published

1976-10-00

Pages

1087-96

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC415496

Subset

External Links

PubMed source DOI: 10.1128/iai.14.4.1087-1096.1976 PMC Full Text View journal details

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Electron microscopic study on the interaction between normal guinea pig peritoneal macrophages and Coxiella burnetii.

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