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PMID: 8283959 Published · ppublish English Journal Article

Ultrastructural localization of urease of Helicobacter pylori.

Medical microbiology and immunology ·Vol. 182 ·No. 5 ·1993-11-00 ·Pages 233-42

Bode G, Malfertheiner P, Lehnhardt G, Nilius M, Ditschuneit H

Abstract

Helicobacter pylori urease was characterized by means of an enzyme histochemical electron microscopic technique. Ultrastructural analysis revealed no urease activity in one strain; in seven H. pylori strains (43.75%), urease activity was associated with the cell membrane. Eight strains (50.0%) showed reaction product located within the cytoplasm. Urease activity showed no correlation with localization of activity. Our results demonstrate that H. pylori urease is not uniform in all H. pylori strains, and differences in activity and localization of urease activity may account for different virulence activities.

MeSH Terms
Helicobacter pylori/enzymology,isolation & purification,ultrastructure Humans Urease/analysis,metabolism
Chemicals
Urease
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Bode G
Department of Internal Medicine I, University of Ulm, Germany.
Malfertheiner P
Lehnhardt G
Nilius M
Ditschuneit H
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Article Info
Journal
Medical microbiology and immunology
Abbr.
Med Microbiol Immunol
ISSN
0300-8584
DOI
10.1007/BF00579622
Published
1993-11-00
Pages
233-42
Language
English
Region
Germany
NLM ID
0314524
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00579622 View journal details
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