Human natural killer (NK) alloreactivity and its association with the major histocompatibility complex: ancestral haplotypes encode particular NK-defined haplotypes.

The Journal of experimental medicine ·Vol. 178 ·No. 3 ·1993-09-01 ·Pages 1033-9

Christiansen FT, Witt CS, Ciccone E, Townend D, Pende D, Viale D, Abraham LJ, Dawkins RL, Moretta L

Abstract

As ancestral haplotypes of the major histocompatibility complex (MHC) appear to define identical MHC haplotypes in unrelated individuals, unrelated individuals sharing the same ancestral haplotype should also share the same NK-defined allospecificities that have recently been shown to map to the human MHC. To test this prediction, multiple cell lines from unrelated individuals sharing the same ancestral haplotypes were tested for the NK-defined allospecificities. It was found that cells sharing the same ancestral haplotypes do have the same NK-defined specificities. Furthermore, the NK-defined phenotype of cells that possess two different ancestral haplotypes can be predicted from the NK-defined phenotypes of unrelated cells that are homozygous for the ancestral haplotypes concerned. Although the group 1 and 2 NK-defined allospecificities can be explained to some extent by HLA-C alleles, evidence is presented that additional genes may modify the phenotype conferred by HLA-C.

MeSH Terms

Alleles Base Sequence Biological Evolution Cytotoxicity, Immunologic HLA-C Antigens/immunology Haplotypes Humans Killer Cells, Natural/immunology Major Histocompatibility Complex Molecular Sequence Data Oligodeoxyribonucleotides/chemistry

Chemicals

HLA-C Antigens Oligodeoxyribonucleotides

Authors & Affiliations

9 authors, click to expand affiliations / ORCID

Christiansen F T

Department of Clinical Immunology, Royal Perth Hospital, Sir Charles Gairdner Hospital, Western Australia.

Witt C S

Ciccone E

Townend D

Pende D

Viale D

Abraham L J

Dawkins R L

Moretta L

References (26)

26 references, click to expand

Rejection of marrow allografts: importance of H-2 homozygosity of donor cells.
Transplantation. 1972 Sep;14(3):289-98 PMID: 4404692
Alloantigen recognition by two human natural killer cell clones is associated with HLA-C or a closely linked gene.
Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):7983-5 PMID: 1518825
C4 allotyping on plasma or serum: application to routine laboratories.
Hum Immunol. 1988 Mar;21(3):165-71 PMID: 3131277
Bone marrow cell transplants involving intra-H-2 recombinant inbred mouse strains. Evidence that hemopoietic histocompatibility-1 (Hh-1) genes are distinct from H-2D or H-2L.
J Immunol. 1988 Oct 1;141(7):2253-60 PMID: 3049802
Specific lysis of allogeneic cells after activation of CD3- lymphocytes in mixed lymphocyte culture.
J Exp Med. 1988 Dec 1;168(6):2403-8 PMID: 2974067
Some disease-associated ancestral haplotypes carry a polymorphism of TNF.
Hum Immunol. 1989 Oct;26(2):91-7 PMID: 2573586
Hemopoietic histocompatibility (Hh-1) regulatory and structural genes of the f haplotype map to H-2.
Transplantation. 1990 Mar;49(3):633-8 PMID: 2316021
Differences in gene copy number carried by different MHC ancestral haplotypes. Quantitation after physical separation of haplotypes by pulsed field gel electrophoresis.
J Exp Med. 1990 Jun 1;171(6):2101-14 PMID: 2351933
Specific recognition of human CD3-CD16+ natural killer cells requires the expression of an autosomic recessive gene on target cells.
J Exp Med. 1990 Jul 1;172(1):47-52 PMID: 1694227
Bone marrow-allograft rejection by T lymphocytes recognizing a single amino acid difference in HLA-B44.
N Engl J Med. 1990 Dec 27;323(26):1818-22 PMID: 2247120
Susceptibility or resistance to lysis by alloreactive natural killer cells is governed by a gene in the human major histocompatibility complex between BF and HLA-B.
Proc Natl Acad Sci U S A. 1990 Dec;87(24):9794-7 PMID: 1979875
Haplotypic polymorphisms of the TNFB gene.
Immunogenetics. 1991;33(1):50-3 PMID: 1671667
Class I-induced resistance to natural killing: identification of nonpermissive residues in HLA-A2.
Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):5989-92 PMID: 2068075
Involvement of HLA class I alleles in natural killer (NK) cell-specific functions: expression of HLA-Cw3 confers selective protection from lysis by alloreactive NK clones displaying a defined specificity (specificity 2).
J Exp Med. 1992 Oct 1;176(4):963-71 PMID: 1328466
Ancestral haplotypes: conserved population MHC haplotypes.
Hum Immunol. 1992 Aug;34(4):242-52 PMID: 1464552
Marrow transplantation from unrelated donors for treatment of hematologic malignancies: effect of mismatching for one HLA locus.
Blood. 1993 Jan 1;81(1):249-53 PMID: 8417795
Generation of allospecific natural killer cells by stimulation across a polymorphism of HLA-C.
Science. 1993 May 21;260(5111):1121-4 PMID: 8493555
HLA class I nucleotide sequences, 1991.
Hum Immunol. 1991 Jul;31(3):195-206 PMID: 1890021
Questions in marrow matching: the implications of ancestral haplotypes for routine practice.
Bone Marrow Transplant. 1991 Aug;8(2):83-6 PMID: 1933062
Evidence of a natural killer (NK) cell repertoire for (allo) antigen recognition: definition of five distinct NK-determined allospecificities in humans.
J Exp Med. 1992 Mar 1;175(3):709-18 PMID: 1371301
Murine natural killer cells and marrow graft rejection.
Annu Rev Immunol. 1992;10:189-213 PMID: 1590985
Sequence differences between HLA-B and TNF distinguish different MHC ancestral haplotypes.
Tissue Antigens. 1992 Mar;39(3):117-21 PMID: 1350870
Ancestral haplotypes carry haplotypic and haplospecific polymorphisms of BAT1: possible relevance to autoimmune disease.
Eur J Immunogenet. 1992 Jun;19(3):121-7 PMID: 1352699
Genomic organization of a polymorphic duplicated region centromeric of HLA-B.
Immunogenetics. 1992;36(4):208-12 PMID: 1353477
Allorecognition by NK cells: nonself or no self?
Immunol Today. 1992 Aug;13(8):300-6 PMID: 1380815
Biology and genetics of hybrid resistance.
Adv Immunol. 1987;41:333-445 PMID: 2891262

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.178.3.1033

Published

1993-09-01

Pages

1033-9

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2191171

Subset

External Links

PubMed source DOI: 10.1084/jem.178.3.1033 PMC Full Text View journal details

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Human natural killer (NK) alloreactivity and its association with the major histocompatibility complex: ancestral haplotypes encode particular NK-defined haplotypes.

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