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PMID: 8380095 Published · ppublish English Clinical Trial Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Experimental vaccine protection against homologous and heterologous strains of feline immunodeficiency virus.

Journal of virology ·Vol. 67 ·No. 1 ·1993-01-00 ·Pages 601-5

Yamamoto JK, Hohdatsu T, Olmsted RA, Pu R, Louie H, Zochlinski HA, Acevedo V, Johnson HM, Soulds GA, Gardner MB

Abstract

More than 90% of cats immunized with inactivated whole infected-cell or cell-free feline immunodeficiency virus (FIV) vaccines were protected against intraperitoneal infection with 10 50% animal infectious doses of either homologous FIV Petaluma (28 of 30 cats) or heterologous FIV Dixon strain (27 of 28 cats). All 15 control cats were readily infected with either strain of FIV. Protection appears to correlate with antiviral envelope antibody levels by a mechanism yet to be determined.

MeSH Terms
Animals Antibodies, Viral/blood Cats Immunodeficiency Virus, Feline/immunology,isolation & purification Lentivirus Infections/immunology,prevention & control,veterinary Specific Pathogen-Free Organisms Vaccination Vaccines, Inactivated/therapeutic use Viral Envelope Proteins/immunology
Chemicals
Antibodies, Viral Vaccines, Inactivated Viral Envelope Proteins
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Yamamoto J K
Department of Medicine, School of Veterinary Medicine, University of California, Davis 95616.
Hohdatsu T
Olmsted R A
Pu R
Louie H
Zochlinski H A
Acevedo V
Johnson H M
Soulds G A
Gardner M B
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15 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.67.1.601-605.1993
Published
1993-01-00
Pages
601-5
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC237403
Subset
IM
Grants
NIAID NIH HHS · AI27732 · United States
NIAID NIH HHS · AI30904 · United States
NCI NIH HHS · CA-39016 · United States
External Links
PubMed source DOI: 10.1128/JVI.67.1.601-605.1993 PMC Full Text View journal details
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