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PMID: 1382145 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Worldwide prevalence of lentivirus infection in wild feline species: epidemiologic and phylogenetic aspects.

Journal of virology ·Vol. 66 ·No. 10 ·1992-10-00 ·Pages 6008-18

Olmsted RA, Langley R, Roelke ME, Goeken RM, Adger-Johnson D, Goff JP, Albert JP, Packer C, Laurenson MK, Caro TM

Abstract

The natural occurrence of lentiviruses closely related to feline immunodeficiency virus (FIV) in nondomestic felid species is shown here to be worldwide. Cross-reactive antibodies to FIV were common in several free-ranging populations of large cats, including East African lions and cheetahs of the Serengeti ecosystem and in puma (also called cougar or mountain lion) populations throughout North America. Infectious puma lentivirus (PLV) was isolated from several Florida panthers, a severely endangered relict puma subspecies inhabiting the Big Cypress Swamp and Everglades ecosystems in southern Florida. Phylogenetic analysis of PLV genomic sequences from disparate geographic isolates revealed appreciable divergence from domestic cat FIV sequences as well as between PLV sequences found in different North American locales. The level of sequence divergence between PLV and FIV was greater than the level of divergence between human and certain simian immunodeficiency viruses, suggesting that the transmission of FIV between feline species is infrequent and parallels in time the emergence of HIV from simian ancestors.

Related Genes
pol
MeSH Terms
Amino Acid Sequence Animals Base Sequence Blotting, Western Carnivora/microbiology Cats Gene Amplification Gene Products, pol/genetics Genes, Viral Immunodeficiency Virus, Feline/classification,genetics,immunology Lentivirus/classification,genetics,immunology Lentivirus Infections/epidemiology,microbiology,veterinary Molecular Sequence Data Phylogeny RNA-Directed DNA Polymerase/genetics Sequence Alignment Species Specificity
Chemicals
Gene Products, pol RNA-Directed DNA Polymerase
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Olmsted R A
Department of Microbiology, Georgetown University, Washington, D.C.
Langley R
Roelke M E
Goeken R M
Adger-Johnson D
Goff J P
Albert J P
Packer C
Laurenson M K
Caro T M
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.66.10.6008-6018.1992
Published
1992-10-00
Pages
6008-18
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC241478
Subset
IM
Grants
NIAID NIH HHS · N01-AI-72623 · United States
Databases
GENBANK
M95470, M95471, M95472, M95473, M95474, M95475, M95476, M95477, M995478
External Links
PubMed source DOI: 10.1128/JVI.66.10.6008-6018.1992 PMC Full Text View journal details
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