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PMID: 2813380 Published · ppublish English Comparative Study Journal Article

Nucleotide sequence analysis of feline immunodeficiency virus: genome organization and relationship to other lentiviruses.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 86 ·No. 20 ·1989-10-00 ·Pages 8088-92

Olmsted RA, Hirsch VM, Purcell RH, Johnson PR

Abstract

We determined the complete nucleotide sequence of an infectious proviral molecular clone (FIV-14) of the feline immunodeficiency virus (FIV). FIV-14 has a genome organization similar in complexity to other lentiviruses. In addition to three large open reading frames representing the gag, pol, and env genes, at least four small open reading frames are present in the pol-env intergenic, env, and env-3' long terminal repeat regions. Nucleotide and deduced amino acid sequence alignments of the FIV coding sequences with analogous sequences of other lentiviruses revealed significant identities only in the gag and pol genes. Phylogenetic tree analyses of gag and pol gene-encoded protein sequences demonstrate that FIV is more closely related to the ungulate lentiviruses, equine infectious anemia virus and visna virus, than to the primate lentiviruses, human and simian immunodeficiency viruses.

MeSH Terms
Animals Base Sequence Biological Evolution Cats DNA, Viral/genetics Genes, Viral Genomic Library HIV-1/genetics Molecular Sequence Data Nucleotide Mapping Phylogeny RNA, Viral/genetics Retroviridae/genetics Species Specificity
Chemicals
DNA, Viral RNA, Viral
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Olmsted R A
Department of Microbiology, Georgetown University, Rockville, MD 20852.
Hirsch V M
Purcell R H
Johnson P R
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.86.20.8088
Published
1989-10-00
Pages
8088-92
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC298220
Subset
IM
Databases
GENBANK
M25381
External Links
PubMed source DOI: 10.1073/pnas.86.20.8088 PMC Full Text View journal details
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