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PMID: 1312825 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Molecular characterization and heterogeneity of feline immunodeficiency virus isolates.

Archives of virology ·Vol. 123 ·No. 1-2 ·1992-00-00 ·Pages 29-45

Maki N, Miyazawa T, Fukasawa M, Hasegawa A, Hayami M, Miki K, Mikami T

Abstract

We have molecularly cloned the complete genomic DNA of TM2 strain of feline immunodeficiency virus (FIV) isolated in Japan and compared its nucleotide and the deduced amino acid sequence with those of previously described U.S. isolates, FIV Petaluma and FIV PPR. The infectious molecular clone of FIV TM2 is different from FIV Petaluma in host cell range; the clone can not infect Crandell feline kidney cells which were permissive for FIV Petaluma. The amino acid sequence homologies, in gag, pol, and env genes between FIV TM2 and Petaluma were 90%, 87%, and 81%, respectively. On the other hand, comparative analysis of each gene between FIV Petaluma and PPR showed 96,95, and 85%, respectively. These results suggested that the genomic diversity was present among FIV strains isolated from geographically distant areas. Interestingly, tat- and rev-like short open reading frames contained inframe stop codons in the FIV Petaluma but not in the FIV TM2.

Related Genes
env gag pol vif
MeSH Terms
Amino Acid Sequence Animals Base Sequence Cats Cells, Cultured Cloning, Molecular DNA, Viral Gene Products, gag/genetics Gene Products, pol/genetics Genes, vif Genome, Viral Immunodeficiency Virus, Feline/genetics,isolation & purification Japan Molecular Sequence Data Open Reading Frames Repetitive Sequences, Nucleic Acid Restriction Mapping Sequence Homology, Nucleic Acid Species Specificity Transfection Viral Envelope Proteins/genetics
Chemicals
DNA, Viral Gene Products, gag Gene Products, pol Viral Envelope Proteins
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Maki N
Fundamental Research Laboratory, Tonen Corporation, Saitama, Japan.
Miyazawa T
Fukasawa M
Hasegawa A
Hayami M
Miki K
Mikami T
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Article Info
Journal
Archives of virology
Abbr.
Arch Virol
ISSN
0304-8608
DOI
10.1007/BF01317136
Published
1992-00-00
Pages
29-45
Language
English
Region
Austria
NLM ID
7506870
Subset
IM
Databases
GENBANK
M59418
External Links
PubMed source DOI: 10.1007/BF01317136 View journal details
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