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PMID: 87519 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Reticuloendotheliosis virus: detection of immunological relationship to mammalian type C retroviruses.

Journal of virology ·Vol. 29 ·No. 3 ·1979-03-00 ·Pages 1221-5

Charman HP, Gilden RV, Oroszlan S

Abstract

Reticuloendotheliosis virus (REV) p30 shares cross-reactive determinants and a common NH2-terminal tripeptide with mammalian type C viral p30's. An interspecies competition radioimmunoassay was developed, using iodinated REV p30 and a broadly reactive antiserum to mammalian virus p30's. The avian leukosis-sarcoma viruses and mammalian non-type C retroviruses did not compete in this assay. Previous data indicating that the REV group is not represented completely in normal avian cell DNA lead us to speculate that this may be the first example of interclass transmission, albeit in the remote past, among the Retroviridae.

MeSH Terms
Animals Epitopes Mammals Molecular Weight RNA Viruses Radioimmunoassay Reticuloendotheliosis virus/analysis,immunology Retroviridae/immunology Viral Proteins/analysis,immunology
Chemicals
Epitopes Viral Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Charman H P
Gilden R V
Oroszlan S
References (22)
22 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
Published
1979-03-00
Pages
1221-5
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC353283
Subset
IM
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