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PMID: 8849232 Published · ppublish English Comparative Study Journal Article

GyrB mutations in Staphylococcus aureus strains resistant to cyclothialidine, coumermycin, and novobiocin.

Antimicrobial agents and chemotherapy ·Vol. 40 ·No. 4 ·1996-04-00 ·Pages 1060-2

Stieger M, Angehrn P, Wohlgensinger B, Gmünder H

Abstract

The sequence of the gyrase B subunit gene from Staphylococcus aureus strains resistant to the gyrase B subunit inhibitors cyclothialidine, coumermycin, and novobiocin has been determined. The residues altered in the resistant gyrase B subunits map to the ATP-binding region, suggesting that the drugs inhibit ATP binding and hydrolysis. The pattern of cross-resistances indicates that the detailed binding mode of the compounds differs.

MeSH Terms
Aminocoumarins Anti-Bacterial Agents/pharmacology Coumarins/pharmacology DNA Gyrase DNA Topoisomerases, Type II/genetics Microbial Sensitivity Tests Mutation Novobiocin/pharmacology Peptides, Cyclic/pharmacology Sequence Homology, Nucleic Acid Staphylococcus aureus/drug effects,genetics
Chemicals
Aminocoumarins Anti-Bacterial Agents Coumarins Peptides, Cyclic cyclothialidine Novobiocin DNA Gyrase DNA Topoisomerases, Type II coumermycin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Stieger M
F. Hoffmann-La Roche, Basel, Switzerland.
Angehrn P
Wohlgensinger B
Gmünder H
References (36)
36 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.40.4.1060
Published
1996-04-00
Pages
1060-2
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC163264
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.40.4.1060 PMC Full Text View journal details
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