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PMID: 8988241 Published · ppublish English Journal Article Review

Molecular machinery mediating vesicle budding, docking and fusion.

Experientia ·Vol. 52 ·No. 12 ·1996-12-15 ·Pages 1021-5

Söllner TH, Rothman JE

Abstract

A general machinery buds and fuses transport vesicles which connect intracellular compartments with each other and allow communication with the extracellular environment. Cytoplasmic coat proteins deform membranes to bud vesicles and interact directly or indirectly with cargo molecules. Compartment-specific SNAREs (SNAP receptors) on vesicles and target membranes dock vesicles and provide a scaffolding for the general fusion machinery to initiate lipid bilayer fusion.

MeSH Terms
Capsid/metabolism Coated Vesicles/metabolism Eukaryotic Cells/metabolism Lipid Bilayers/metabolism Membrane Fusion/physiology Membrane Proteins/metabolism Models, Biological SNARE Proteins Synaptic Vesicles/metabolism Vesicular Transport Proteins
Chemicals
Lipid Bilayers Membrane Proteins SNARE Proteins Vesicular Transport Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Söllner T H
Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Rothman J E
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Article Info
Journal
Experientia
Abbr.
Experientia
ISSN
0014-4754
DOI
10.1007/BF01952097
Published
1996-12-15
Pages
1021-5
Language
English
Region
Switzerland
NLM ID
0376547
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01952097
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