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PMID: 8990281 Published · ppublish English Journal Article

Contribution of horizontal gene transfer and deletion events to development of distinctive patterns of fimbrial operons during evolution of Salmonella serotypes.

Journal of bacteriology ·Vol. 179 ·No. 2 ·1997-01-00 ·Pages 317-22

Bäumler AJ, Gilde AJ, Tsolis RM, van der Velden AW, Ahmer BM, Heffron F

Abstract

Only certain serotypes of Salmonella represent 99% of all human clinical isolates. We determined whether the phylogenetic distribution of fimbrial operons would account for the host adaptations observed for Salmonella serotypes. We found that three fimbrial operons, fim, lpf, and agf, were present in a lineage ancestral to Salmonella. While the fim and agf fimbrial operons were highly conserved among all Salmonella serotypes, sequence analysis suggested that the lpf operon was lost from many distantly related lineages. As a consequence, the distribution of the lpf operon cannot be explained easily and may be a consequence of positive and negative selection in different hosts for the presence of these genes. Two other fimbrial operons, sef and pef, each entered two distantly related Salmonella lineages and each is present only in a small number of serotypes. These results show that horizontal gene transfer and deletion events have created unique combinations of fimbrial operons among Salmonella serotypes. The presence of sef and pef correlated with serotypes frequently isolated from common domesticated animals.

MeSH Terms
Chromosomes, Bacterial Escherichia coli/genetics Evolution, Molecular Fimbriae, Bacterial/genetics Gene Deletion Operon Phylogeny Salmonella/classification,genetics Salmonella typhimurium/genetics Sequence Homology, Nucleic Acid Serotyping
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Bäumler A J
Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland 97201-3098, USA.
Gilde A J
Tsolis R M
van der Velden A W
Ahmer B M
Heffron F
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.179.2.317-322.1997
Published
1997-01-00
Pages
317-22
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC178699
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.179.2.317-322.1997 PMC Full Text View journal details
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