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PMID: 9060691 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Human immunodeficiency virus strains differ in their ability to infect CD4+ cells expressing the rat homolog of CXCR-4 (fusin).

Journal of virology ·Vol. 71 ·No. 4 ·1997-04-00 ·Pages 3259-62

Pleskoff O, Sol N, Labrosse B, Alizon M

Abstract

A clade B strain of human immunodeficiency virus type 1 (HIV-1(LAI)) could infect CD4+ cells expressing human CXCR-4 (fusin) or its rat homolog with similar efficacy. By contrast, cells expressing rat CXCR-4 were not permissive to HIV-1(NDK) (clade D), HIV-2(ROD), or HIV-1(LAI) with chimeric envelope protein gp120 bearing the V3 domain from HIV-1(NDK). The reciprocal chimeric gp120 (HIV-1(NDK) with V3 from HIV-1(LAI)) could mediate infection of cells expressing either human or rat CXCR-4. Genetically divergent HIV strains have different requirements for interaction with the CXCR-4 coreceptor, and the gp120 V3 domain seems to be involved in this interaction.

MeSH Terms
Animals CD4-Positive T-Lymphocytes/metabolism,virology HIV Core Protein p24/analysis HIV Envelope Protein gp120/genetics,immunology HIV-1/classification,genetics,physiology HIV-2/classification,physiology HeLa Cells Humans Membrane Proteins/biosynthesis,genetics,physiology Peptide Fragments/genetics,immunology Rats Receptors, CXCR4 Receptors, HIV/biosynthesis,genetics,physiology Recombinant Fusion Proteins/genetics Species Specificity Tumor Cells, Cultured
Chemicals
HIV Core Protein p24 HIV Envelope Protein gp120 HIV envelope protein gp120 (305-321) Membrane Proteins Peptide Fragments Receptors, CXCR4 Receptors, HIV Recombinant Fusion Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Pleskoff O
INSERM U.332, Institut Cochin de Génetique Moleculaire, Paris, France.
Sol N
Labrosse B
Alizon M
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.71.4.3259-3262.1997
Published
1997-04-00
Pages
3259-62
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC191460
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.71.4.3259-3262.1997 PMC Full Text View journal details
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