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PMID: 9271118 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

eyelid antagonizes wingless signaling during Drosophila development and has homology to the Bright family of DNA-binding proteins.

Genes & development ·Vol. 11 ·No. 15 ·1997-08-01 ·Pages 1949-62

Treisman JE, Luk A, Rubin GM, Heberlein U

Abstract

In Drosophila, pattern formation at multiple stages of embryonic and imaginal development depends on the same intercellular signaling pathways. We have identified a novel gene, eyelid (eld), which is required for embryonic segmentation, development of the notum and wing margin, and photoreceptor differentiation. In these tissues, eld mutations have effects opposite to those caused by wingless (wg) mutations. eld encodes a widely expressed nuclear protein with a region homologous to a novel family of DNA-binding domains. Based on this homology and on the phenotypic analysis, we suggest that Eld could act as a transcription factor antagonistic to the Wg pathway.

MeSH Terms
Amino Acid Sequence Animals Body Patterning/genetics Cell Differentiation Cloning, Molecular DNA-Binding Proteins/analysis,genetics,physiology Drosophila/embryology,genetics,growth & development Drosophila Proteins Gene Expression Regulation, Developmental Genes, Insect/genetics Molecular Sequence Data Mutation Phenotype Photoreceptor Cells, Invertebrate/chemistry,cytology,growth & development Proto-Oncogene Proteins/physiology Recombinant Fusion Proteins Restriction Mapping Sequence Homology, Amino Acid Signal Transduction/physiology Trans-Activators/genetics Transcription Factors/analysis,genetics,physiology Wings, Animal/growth & development Wnt1 Protein
Chemicals
DNA-Binding Proteins Drosophila Proteins Proto-Oncogene Proteins Recombinant Fusion Proteins Trans-Activators Transcription Factors Wnt1 Protein osa protein, Drosophila wg protein, Drosophila
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Treisman J E
Skirball Institute of Biomolecular Medicine, NYU Medical Center, New York, New York 10016, USA. [email protected]
Luk A
Rubin G M
Heberlein U
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Article Info
Journal
Genes & development
Abbr.
Genes Dev
ISSN
0890-9369
DOI
10.1101/gad.11.15.1949
Email
[email protected]
Published
1997-08-01
Pages
1949-62
Language
English
Region
United States
NLM ID
8711660
PMCID
PMC316407
Subset
IM
Grants
NEI NIH HHS · EY11410 · United States
NIGMS NIH HHS · GM33135 · United States
Databases
GENBANK
AF053091
External Links
PubMed source DOI: 10.1101/gad.11.15.1949 PMC Full Text View journal details
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