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PMID: 9601053 Published · ppublish English Journal Article Review

The extended protein kinase C superfamily.

The Biochemical journal ·Vol. 332 ( Pt 2) ·1998-06-01 ·Pages 281-92

Mellor H, Parker PJ

Abstract

Members of the mammalian protein kinase C (PKC) superfamily play key regulatory roles in a multitude of cellular processes, ranging from control of fundamental cell autonomous activities, such as proliferation, to more organismal functions, such as memory. However, understanding of mammalian PKC signalling systems is complicated by the large number of family members. Significant progress has been made through studies based on comparative analysis, which have defined a number of regulatory elements in PKCs which confer specific location and activation signals to each isotype. Further studies on simple organisms have shown that PKC signalling paradigms are conserved through evolution from yeast to humans, underscoring the importance of this family in cellular signalling and giving novel insights into PKC function in complex mammalian systems.

MeSH Terms
Amino Acid Sequence Animals Conserved Sequence/genetics Evolution, Molecular Fungal Proteins/chemistry Helminth Proteins/chemistry Humans Isoenzymes/chemistry Mammals Molecular Sequence Data Protein Kinase C/chemistry Signal Transduction/physiology
Chemicals
Fungal Proteins Helminth Proteins Isoenzymes Protein Kinase C
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Mellor H
Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.
Parker P J
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj3320281
Published
1998-06-01
Pages
281-92
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1219479
Subset
IM
External Links
PubMed source DOI: 10.1042/bj3320281 PMC Full Text View journal details
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