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PMID: 9714747 Published · ppublish English Journal Article Review

Protein sorting in the Golgi complex.

Biochimica et biophysica acta ·Vol. 1404 ·No. 1-2 ·1998-08-14 ·Pages 77-84

Füllekrug J, Nilsson T

Abstract

Even after one hundred years, the Golgi apparatus remains a major challenge in the field of Cell Biology. This is particularly true in terms of transport and of protein sorting. For example, the question how cargo proteins are transported through this organelle is still a matter of debate. Emphasis has been put on the role of anterograde and retrograde transport vesicles. These have been proposed to carry cargo from cisterna to cisterna and to recycle components needed for further rounds of transport. Alternatively, anterograde movement of cargo takes place in cisternal membranes rather than transport vesicles. These membranes assemble and mature in a cis to trans direction. In this case, retrograde transport vesicles need to recycle all components of the Golgi apparatus and this demands a highly dynamic and efficient sorting machinery. Here we will discuss possible mechanisms for protein sorting in the context of cisternal maturation and propose that a common mechanism is sufficient to explain both transport of cargo and sorting of resident proteins.

MeSH Terms
Carrier Proteins/metabolism Endoplasmic Reticulum/metabolism Golgi Apparatus/metabolism Humans Intracellular Membranes/metabolism,physiology Proteins/metabolism
Chemicals
Carrier Proteins Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Füllekrug J
Cell Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69012 Heidelberg, Germany.
Nilsson T
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Article Info
Journal
Biochimica et biophysica acta
Abbr.
Biochim Biophys Acta
ISSN
0006-3002
DOI
10.1016/s0167-4889(98)00048-2
Published
1998-08-14
Pages
77-84
Language
English
Region
Netherlands
NLM ID
0217513
PMCID
PMC7127375
Subset
IM
External Links
PubMed source DOI: 10.1016/s0167-4889(98)00048-2 PMC Full Text
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