Home LiteratureArticle Details
PMID: 9764030 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Bacterial factors and immune pathogenesis in Helicobacter pylori infection.

Gut ·Vol. 43 Suppl 1 ·1998-07-00 ·Pages S2-5

Shimoyama T, Crabtree JE

Abstract

Virulent Helicobacter pylori strains which have been clinically associated with severe outcome induce increased gastric mucosal immune responses. Although several bacterial pathogenic factors have been shown to have a considerable role in H pylori infection, variability in host immune responses may also contribute to mucosal damage in H pylori associated gastritis.

MeSH Terms
Antigens, Bacterial/genetics Bacterial Proteins/genetics Gastric Mucosa/immunology,microbiology Gastritis/immunology,microbiology Helicobacter Infections/immunology Helicobacter pylori/genetics,immunology,pathogenicity Humans Immunity, Mucosal Lymphocyte Activation Neutrophil Activation Virulence
Chemicals
Antigens, Bacterial Bacterial Proteins VacA protein, Helicobacter pylori cagA protein, Helicobacter pylori
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Shimoyama T
First Department of Internal Medicine, Hirosaki University School of Medicine, Japan.
Crabtree J E
References (57)
57 references, click to expand
  1. Gastric mucosal secretion of interleukin-10: relations to histopathology, Helicobacter pylori status, and tumour necrosis factor-alpha secretion.
    Gut. 1997 Jun;40(6):739-44 PMID: 9245927
  2. Gastric mucosal inflammatory responses to Helicobacter pylori.
    Aliment Pharmacol Ther. 1996 Apr;10 Suppl 1:29-37 PMID: 8730257
  3. Differential stimulation of interleukin-12 (IL-12) and IL-10 by live and killed Helicobacter pylori in vitro and association of IL-12 production with gamma interferon-producing T cells in the human gastric mucosa.
    Infect Immun. 1997 Oct;65(10):4229-35 PMID: 9317031
  4. Cytotoxic activity in broth-culture filtrates of Campylobacter pylori.
    J Med Microbiol. 1988 Jun;26(2):93-9 PMID: 3385767
  5. Cytotoxin production by Campylobacter pylori strains isolated from patients with peptic ulcers and from patients with chronic gastritis only.
    J Clin Microbiol. 1989 Jan;27(1):225-6 PMID: 2913034
  6. Interaction of campylobacter species with antibody, complement and phagocytes.
    Gut. 1989 Jul;30(7):906-11 PMID: 2788111
  7. Relation between T cell number and epithelial HLA class II expression quantified by image analysis in normal and inflamed human gastric mucosa.
    Gut. 1990 Jun;31(6):647-52 PMID: 2199346
  8. Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology.
    Lancet. 1991 Aug 10;338(8763):332-5 PMID: 1677696
  9. Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori associated gastritis.
    Gut. 1991 Dec;32(12):1473-7 PMID: 1773951
  10. Low biological activity of Helicobacter pylori lipopolysaccharide.
    Infect Immun. 1992 Apr;60(4):1714-6 PMID: 1548097
  11. Purification and characterization of the vacuolating toxin from Helicobacter pylori.
    J Biol Chem. 1992 May 25;267(15):10570-5 PMID: 1587837
  12. Tumor necrosis factor alpha and interferon gamma synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kB-like binding sites of the interleukin 8 gene.
    J Biol Chem. 1992 Nov 5;267(31):22506-11 PMID: 1331059
  13. Immunological activity of lipopolysaccharide of Helicobacter pylori on human peripheral mononuclear blood cells in comparison to lipopolysaccharides of other intestinal bacteria.
    FEMS Immunol Med Microbiol. 1993 Apr;6(4):317-24 PMID: 8499895
  14. Lewis blood group-related antigen expression in normal gastric epithelium, intestinal metaplasia, gastric adenoma, and gastric carcinoma.
    Am J Gastroenterol. 1993 Jun;88(6):919-24 PMID: 8503388
  15. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer.
    Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5791-5 PMID: 8516329
  16. Mechanisms involved in Helicobacter pylori-induced inflammation.
    Gastroenterology. 1993 Nov;105(5):1431-40 PMID: 7901109
  17. Systemic and mucosal humoral responses to Helicobacter pylori in gastric cancer.
    Gut. 1993 Oct;34(10):1339-43 PMID: 8244098
  18. Immunobiological activities of Helicobacter pylori porins.
    Infect Immun. 1994 Apr;62(4):1392-9 PMID: 8132346
  19. Interleukin-8 expression in Helicobacter pylori infected, normal, and neoplastic gastroduodenal mucosa.
    J Clin Pathol. 1994 Jan;47(1):61-6 PMID: 8132812
  20. Neutrophil activation by Helicobacter pylori lipopolysaccharides.
    J Infect Dis. 1994 Jul;170(1):135-9 PMID: 8014489
  21. Mucosal tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8 production in patients with Helicobacter pylori infection.
    Scand J Gastroenterol. 1994 May;29(5):425-9 PMID: 8036458
  22. CagA/cytotoxic strains of Helicobacter pylori and interleukin-8 in gastric epithelial cell lines.
    J Clin Pathol. 1994 Oct;47(10):945-50 PMID: 7962609
  23. Identification of four new prokaryotic bacterioferritins, from Helicobacter pylori, Anabaena variabilis, Bacillus subtilis and Treponema pallidum, by analysis of gene sequences.
    Gene. 1995 Feb 3;153(1):123-7 PMID: 7883175
  24. Interferon gamma and interleukin 4 secreting cells in the gastric antrum in Helicobacter pylori positive and negative gastritis.
    Gut. 1995 Mar;36(3):341-5 PMID: 7698689
  25. Helicobacter pylori induced interleukin-8 expression in gastric epithelial cells is associated with CagA positive phenotype.
    J Clin Pathol. 1995 Jan;48(1):41-5 PMID: 7706517
  26. Decrease in gastric permeability to sucrose following cure of Helicobacter pylori infection.
    Helicobacter. 1997 Mar;2(1):44-7 PMID: 9432322
  27. Analyses of the cag pathogenicity island of Helicobacter pylori.
    Mol Microbiol. 1998 Apr;28(1):37-53 PMID: 9593295
  28. The role of lipopolysaccharide in Helicobacter pylori pathogenesis.
    Aliment Pharmacol Ther. 1996 Apr;10 Suppl 1:39-50 PMID: 8730258
  29. Antigenic mimicry between Helicobacter pylori and gastric mucosa in the pathogenesis of body atrophic gastritis.
    Gastroenterology. 1996 Sep;111(3):655-65 PMID: 8780570
  30. Expression of cytokine mRNA in gastric mucosa with Helicobacter pylori infection.
    Scand J Gastroenterol. 1995 Dec;30(12):1153-9 PMID: 9053967
  31. Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cells.
    Mol Microbiol. 1995 Dec;18(5):867-76 PMID: 8825091
  32. Characterization of lymphocytic infiltrates in Helicobacter pylori-associated gastritis.
    Scand J Gastroenterol. 1996 Mar;31(3):222-8 PMID: 8833350
  33. Antibodies to CagA protein are associated with gastric atrophy in Helicobacter pylori infection.
    Eur J Gastroenterol Hepatol. 1996 Jul;8(7):645-9 PMID: 8853252
  34. Expression of the human cell surface glycoconjugates Lewis x and Lewis y by Helicobacter pylori isolates is related to cagA status.
    Infect Immun. 1996 Nov;64(11):4598-605 PMID: 8890213
  35. cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors.
    Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14648-53 PMID: 8962108
  36. Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori.
    Gastroenterology. 1997 Jan;112(1):92-9 PMID: 8978347
  37. Epithelium related deposition of activated complement in Helicobacter pylori associated gastritis.
    Gut. 1997 Feb;40(2):196-203 PMID: 9071931
  38. Expression of B7-1 and B7-2 costimulatory molecules by human gastric epithelial cells: potential role in CD4+ T cell activation during Helicobacter pylori infection.
    J Clin Invest. 1997 Apr 1;99(7):1628-36 PMID: 9120006
  39. Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection.
    Gut. 1997 Mar;40(3):297-301 PMID: 9135515
  40. Pattern of adhesion molecule expression on vascular endothelium in Helicobacter pylori-associated antral gastritis.
    Gastroenterology. 1997 Jun;112(6):1908-19 PMID: 9178683
  41. Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan.
    J Clin Microbiol. 1997 Jul;35(7):1710-4 PMID: 9196179
  42. Interleukin-8 response of gastric epithelial cell lines to Helicobacter pylori stimulation in vitro.
    Infect Immun. 1995 May;63(5):1681-87 PMID: 7729872
  43. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach.
    Cancer Res. 1995 May 15;55(10):2111-5 PMID: 7743510
  44. Characterization of a Helicobacter pylori neutrophil-activating protein.
    Infect Immun. 1995 Jun;63(6):2213-20 PMID: 7768601
  45. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration.
    J Biol Chem. 1995 Jul 28;270(30):17771-7 PMID: 7629077
  46. Low pH activates the vacuolating toxin of Helicobacter pylori, which becomes acid and pepsin resistant.
    J Biol Chem. 1995 Oct 13;270(41):23937-40 PMID: 7592587
  47. Helicobacter pylori and atrophic gastritis: importance of the cagA status.
    J Natl Cancer Inst. 1995 Dec 6;87(23):1777-80 PMID: 7473834
  48. Heightened inflammatory response and cytokine expression in vivo to cagA+ Helicobacter pylori strains.
    Lab Invest. 1995 Dec;73(6):760-70 PMID: 8558837
  49. Induction of interleukin-8 secretion from gastric epithelial cells by a cagA negative isogenic mutant of Helicobacter pylori.
    J Clin Pathol. 1995 Oct;48(10):967-9 PMID: 8537502
  50. Lipopolysaccharide of the Helicobacter pylori type strain NCTC 11637 (ATCC 43504): structure of the O antigen chain and core oligosaccharide regions.
    Biochemistry. 1996 Feb 20;35(7):2489-97 PMID: 8652593
  51. Lipopolysaccharides of Helicobacter pylori strains P466 and MO19: structures of the O antigen and core oligosaccharide regions.
    Biochemistry. 1996 Feb 20;35(7):2498-504 PMID: 8652594
  52. The interrelationship between cytotoxin-associated gene A, vacuolating cytotoxin, and Helicobacter pylori-related diseases.
    J Infect Dis. 1996 May;173(5):1171-5 PMID: 8627069
  53. Helicobacter-specific cell-mediated immune responses display a predominant Th1 phenotype and promote a delayed-type hypersensitivity response in the stomachs of mice.
    J Immunol. 1996 Jun 15;156(12):4729-38 PMID: 8648119
  54. Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunity.
    Infect Immun. 1996 Jun;64(6):2031-40 PMID: 8675304
  55. Helicobacter pylori cagA gene and expression of cytokine messenger RNA in gastric mucosa.
    Gastroenterology. 1996 Jun;110(6):1744-52 PMID: 8964399
  56. Helicobacter pylori urease is a potent stimulus of mononuclear phagocyte activation and inflammatory cytokine production.
    Gastroenterology. 1996 Aug;111(2):419-25 PMID: 8690207
  57. Different cytokine profile and antigen-specificity repertoire in Helicobacter pylori-specific T cell clones from the antrum of chronic gastritis patients with or without peptic ulcer.
    Eur J Immunol. 1997 Jul;27(7):1751-5 PMID: 9247587
Article Info
Journal
Gut
Abbr.
Gut
ISSN
0017-5749
Published
1998-07-00
Pages
S2-5
Language
English
Region
England
NLM ID
2985108R
PMCID
PMC1766604
Subset
IM
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2