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Acute promyelocytic leukemia with a novel TTMV::RARA fusion initially presentin…

Ruijia(L),Qianqian(Z),Xiaohong(L),Sen(Y),Nan… Front Oncol None

...RARA fusions in APL-like cases lacking PML::RARA. TTMV::RARA APL may be sensitive to ATRA/ATO-based therapy; however, th...

Current views on the genetic landscape and management of variant acute promyelo…

Zhang(X),Sun(J),Yu(W),Jin(J) Biomark Res 2021-05-06

...RARA, NUMA-RARA, FIP1L1-RARA, IRF2BP2-RARA, and TFG-RARA have been demonstrated to be sensitive to ATRA, so combined che...

Glomerular basement membrane: lamina rara, lamina densa.

Martinez-Hernandez(A),Marsh(CA),Horn(JF),Mun… Ren Physiol 1981-00-00

...rara and lamina densa. Our results indicate that the lamina rara is not a fixation artifact and it has common antigenic ...

Diagnosis of acute promyelocytic leukaemia by RT-PCR: detection of PML-RARA and…

Borrow(J),Goddard(AD),Gibbons(B),Katz(F),Swi… Br J Haematol 1992-11-00

...RARA fusion message. Separate PCR assays were designed to amplify either PML-RARA (15q+ derived) or RARA-PML (17q- deriv...

MIR125B1 represses the degradation of the PML-RARA oncoprotein by an autophagy-…

Zeng(CW),Chen(ZH),Zhang(XJ),Han(BW),Lin(KY),… Autophagy 2014-10-01

...RARA status. MIR125B1 overexpression enhanced PML-RARA expression and inhibited the ATRA-induced degradation of the PML-...

Case report of pediatric TTMV-related acute promyelocytic leukemia with central…

Wang(L),Chen(J),Hou(B),Wu(Y),Yang(J),Zhou(X)… Heliyon 2024-03-15

...RARA-APL and subsequent administration of two rounds of ATRA-based treatment, the patient rapidly developed multiple RAR...

PML-RARA fusion transcripts in irradiated and normal hematopoietic cells.

Quina(AS),Gameiro(P),Sá da Costa(M),Telhada(… Genes Chromosomes Cancer 2000-11-00

...RARA transcripts was analyzed by a highly sensitive PCR assay. Despite gene proximity, typical PML-RARA transcripts were...

A new transcriptional variant and small azurophilic granules in an acute promye…

Kikuma(Tomoe),Nakamachi(Yuji),Noguchi(Yoriko… Int J Hematol 2016-09-26

...RARA fusion transcripts derived from a combination of NPM1 exon 4 and RARA exon 5, or of NPM1 exon 1 and RARA exon 5; th...

Zebrafish modeling of atypical PML-RARA isoform from acute promyelocytic leukem…

Ye(Y),Zhao(Z),Mo(W),Liu(W),Wu(L),Li(J),Zhang… Ann Hematol 2025-01-00

Acute promyelocytic leukemia (APL) is driven by the specific fusion gene PML-RARA produced by chromosomal translocation....

PML/RARA oxidation and arsenic binding initiate the antileukemia response of As…

Jeanne(M),Lallemand-Breitenbach(V),Ferhi(O),… Cancer Cell 2010-07-13

...RARA mutant exhibit defective As(2)O(3) response. Conversely, nonarsenical oxidants elicit PML/RARA multimerization, NB-...

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