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PML/RARA oxidation and arsenic binding initiate the antileukemia response of As…

Jeanne(M),Lallemand-Breitenbach(V),Ferhi(O),… Cancer Cell 2010-07-13

...RARA mutant exhibit defective As(2)O(3) response. Conversely, nonarsenical oxidants elicit PML/RARA multimerization, NB-...

OBFC2A/RARA: a novel fusion gene in variant acute promyelocytic leukemia.

Won(D),Shin(SY),Park(CJ),Jang(S),Chi(HS),Lee… Blood 2013-02-21

...RARA and oligonucleotide/oligosaccharide-binding fold containing 2A (OBFC2A) genes. Sequence analysis of the OBFC2A/RARA...

Synergy against PML-RARa: targeting transcription, proteolysis, differentiation…

Dos Santos(GA),Kats(L),Pandolfi(PP) J Exp Med 2013-12-16

...RARa acts as a transcriptional repressor of RARa and non-RARa target genes and antagonizes the formation and function of...

Myeloid Sarcoma Type of Acute Promyelocytic Leukemia With a Cryptic Insertion o…

Wang(Y),Rui(Y),Shen(Y),Li(J),Liu(P),Lu(Q),Fa… Front Oncol 2021-00-00

...RARA fusion gene has recently been reported as a novel RARA-associated fusion gene. We report a case of de novo myeloid ...

Cloning and expression of recombinant arazyme with anti-inflammatory and anti-b…

Yahyaee(Z),Shahpari(M),Mousavi Ghahfarrokhi(… Arch Microbiol 2024-06-22

...rAra to study anti-breast cancer potentials using MTT assay. The anti-inflammatory property of rAra was investigated usi...

Detection of the STAT5B-RARA fusion transcript in acute promyelocytic leukemia …

Kusakabe(M),Suzukawa(K),Nanmoku(T),Obara(N),… Eur J Haematol 2008-05-00

...RARA) with a number of alternative partner genes. Signal transducer and activator of transcription 5 beta (STAT5B) is on...

Critical role of tripartite fusion and LBD truncation in certain RARA- and all …

Zhou(X),Chen(X),Chen(J),Wen(L),Zhang(Z),Qin(… Blood 2024-00-03

...RARA fusion. Among these, 31 individually rare RARA and RARG fusion genes have been documented, often reported in the ca...

The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-r…

Redner(RL),Rush(EA),Faas(S),Rudert(WA),Corey… Blood 1996-02-01

...RARA). Two alternatively spliced transcripts are expressed, which differ in 129 bases immediately upstream of the RARA s...

Eradication of acute promyelocytic leukemia-initiating cells by PML/RARA-target…

Nasr(R),de Thé(H) Int J Hematol 2010-06-00

...RARA fusion protein. Expression of PML/RARA, a potent transcriptional repressor, induces APL in mice. Both retinoic acid...

Varying responses of PML-RARA with different genetic mutations to arsenic triox…

Liu(Jiangying),Zhu(Hong-Hu),Jiang(Hao),Jiang… Blood 2016-06-05

...RARA mutations in mediating resistance to arsenic trioxide. Among the 5-point mutations in the PML part of PML-RARA iden...

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