Gangjee(Aleem),Lin(Xin),Kisliuk(Roy L),McGui… J Med Chem 2006-01-17

...FPGS) substrates. Compound 3 also inhibited the growth of several human tumor cell lines in culture with GI50 < 10(-8) M...

Smith(Clyde A),Cross(Jennifer A),Bognar(Andr… Acta Crystallogr D Biol Cryst… 2006-07-05

...FPGS (apoFPGS), maintained in the absence of Mg(2+) by a hydrogen-bonding network involving water molecules in the activ...

Barbado(Maud),Preisser(Laurence),Boisdron-Ce… Cancer Lett 2006-12-12

...FPGS). A frame-shifted artificial construct was designed specifically to work within the same conditions. We validated o...

Tan(Xiao-Jian),Carlson(Heather A) J Med Chem 2006-02-09

Folylpolyglutamate synthetase (FPGS) catalyzes the sequential addition of several glutamates to folate, forming gamma-li...

Wettergren(Yvonne),Odin(Elisabeth),Nilsson(S… Cancer Detect Prev 2006-04-11

...FPGS) had impact on the expression of DCC splice variants.,Quantification of RFC-1 and FPGS expression in mucosa of 53 C...

DeMartino(Jessica K),Hwang(Inkyu),Xu(Lan),Wi… J Med Chem 2006-06-06

...FPGS) expression levels and polyglutamation.

Amara(Patricia),Serre(Laurence) DNA Repair (Amst) 2006-10-24

...Fpgs to distinguish a damaged guanine from a normal nucleotide.

Young(P G),Smith(C A),Sun(X),Baker(E N),Metc… Acta Crystallogr Sect F Struc… 2006-08-04

...FPGS (MtbFPGS; Rv2447c) has been cloned and the protein (51 kDa) expressed in Escherichia coli. The purified protein was...

Yki-Järvinen(H),Kauppinen-Mäkelin(R),Tiikkai… Diabetologia 2006-11-21

...FPGs averaged 5.75+/-0.02 and 5.96+/-0.03 mmol/l (p<0.001) and insulin doses were 68+/-5 and 70+/-6 IU/day (0.69+/-0.05 ...

Gangjee(Aleem),Jain(Hiteshkumar D),Phan(Jacl… J Med Chem 2006-03-29

...FPGS. Metabolite protection studies established TS as its principal target. Most of the nonclassical analogues were only...