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Association of folylpolyglutamate synthase polymorphisms with methotrexate resp…

Lee(YH),Song(GG) Pharmacogenomics J 2026-04-03

This meta-analysis evaluated the association between FPGS gene polymorphisms (rs10106 (1994A > G) and rs1544105 (2572 C ...

Identification of vulnerable antimalarial targets using conditional loss of fun…

Shaw(PJ),Prommana(P),Wongsombat(C),Pengon(J)… Mol Biochem Parasitol 2026-09-00

...FPGS, and GAT as new vulnerable targets.

Rapid on-off effects of methotrexate on lymphocytes may facilitate recovery of …

Jeong(H),Yang(S),Park(JW),Winthrop(K),Lee(EB… Front Immunol None

...FPGS), and γ-glutamyl hydrolase (GGH) was quantified. A post-hoc analysis of two clinical trials including 318 RA patien...

Population Pharmacokinetic Analysis of Factors Affecting the Clearance of Metho…

Hakamata(J),Kaneko(Y),Shimizu(M),Takeuchi(T)… Mod Rheumatol 2026-08-13

...FPGS, GGH) related to MTX metabolism, were evaluated as covariates. Population pharmacokinetic analysis was performed us...

Factorization of Alzheimer's disease genetic risk influences allow patient stra…

Pelletier(A),Tuck(T),Tcw(J) bioRxiv 2026-01-08

...fPGS were predicting a certain neuropathological or AD-associated molecular condition. Notably, fPGS3 predicts somatic m...

The impact of gene polymorphisms on the response of methotrexate-based treatmen…

Esperón(P),Vital(M),Giletti(A) Eur J Clin Pharmacol 2026-05-09

...FPGS rs1544105 T allele has shown an association with diverse toxicities in ALL pediatric patients. Although considerabl...

Prognostic score methods for the estimation of the average causal effect.

Porage(C),Waernbaum(I) Int J Biostat 2026-05-01

...FPGS and a version of FPGS using conditional expectations of the outcomes, meet the sufficiency condition for confoundin...

Selectively Targeting Leukemic MOLT-4 Cells by MTX-cIBR Conjugate: Mechanism of…

Werdyani(S),Weldele(ME),Istyastono(EP),Harja… Life (Basel) 2026-06-11

...FPGS, and TYMS in MOLT-4 cells. Computational analyses further demonstrated that MTX exhibited lower binding free energy...

Pharmacodynamic determinants of mitochondrial one-carbon flux and serine hydrox…

Schneider(M),O'Connor(C),Bao(X),Nayeen(MJ),M… Drug Metab Dispos 2025-08-00

...FPGS). Folate transporter-null HeLa cells were engineered to express RFC under the control of a tetracycline-inducible p...

Polyamine metabolism genes of maize (Zea mays) downregulated during compatible …

Przybylska(A) Mol Biol Rep 2025-10-16

...FPGS). In the case of the spermine synthase coding gene, significant upregulation was first observed, followed by downre...

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