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FPGS

Gene name:folylpolyglutamate synthase

...FPGS在增殖活跃的组织(如骨髓、肠道上皮和肿瘤)中表达较高,因为这些组织对叶酸需求旺盛。FPGS基因突变可能导致叶酸代谢障碍,引发巨幼红细胞性贫血、神经管缺陷或癌症风险增加。FPGS过表达会增强叶酸代谢通路的活性,促进核苷酸合成和细胞增殖...

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