Odin(Elisabeth),Wettergren(Yvonne),Carlsson(… Clin Colorectal Cancer 2006-04-28

...FPGS) and to investigate the impact of folate concentration on patients with CRC with different MTHFR genotypes.,The fre...

Gangjee(Aleem),Jain(Hiteshkumar D),Phan(Jacl… J Med Chem 2006-03-29

...FPGS. Metabolite protection studies established TS as its principal target. Most of the nonclassical analogues were only...

Kidd(Elizabeth A),Yu(Jinsheng),Li(Xia),Shann… Clin Cancer Res 2005-08-08

...FPGS, DHFR, GGH, NME1, NME2, RRM2, UMPH2, UNG, UMPS, TP53, and TK1), a significant proportion of the patients showed an ...

Fotoohi(Kambiz),Jansen(Gerrit),Assaraf(Yehud… Blood 2005-03-24

...FPGS) activity, which conferred more than 100-fold MTX resistance upon a short-term exposure to this drug. This is the f...

Chong(Youhoon),Hwang(Inkyu),Tavassoli(Ali),Z… Bioorg Med Chem 2005-09-08

...FPGS polyglutamylation.

Kim(Jee Hyun),Lee(Keun-Wook),Jung(Yeonjoo),K… Cancer Sci 2005-08-04

...FPGS) and reduced folate carrier (RFC1) were performed in order to determine whether sensitivity to pemetrexed would be ...

Tomsho(John W),McGuire(John J),Coward(James … Org Biomol Chem 2005-12-12

Folylpoly-gamma-glutamate synthetase (FPGS, EC 6.3.2.17) catalyzes the ATP-dependent ligation of glutamic acid to reduce...

Gangjee(Aleem),Zeng(Yibin),McGuire(John J),K… J Med Chem 2005-09-27

...FPGS) as well as antitumor activity. Extension of the bridge homologation studies of classical two-carbon bridged antifo...

Nair(Jayakumar R),McGuire(John J) Biochim Biophys Acta 2005-12-14

...FPGS) exists as cytosolic and mitochondrial (mFPGS) isoforms. Localization of mFPGS within mitochondria may help elucida...

Benepal(T S),Judson(I) Anticancer Drugs 2005-06-28

...FPGS), whilst potentially reducing the toxicities associated with polyglutamation and drug retention in normal tissues. ...