Tomsho(John W),McGuire(John J),Coward(James … Org Biomol Chem 2005-12-12

Folylpoly-gamma-glutamate synthetase (FPGS, EC 6.3.2.17) catalyzes the ATP-dependent ligation of glutamic acid to reduce...

Nair(Jayakumar R),McGuire(John J) Biochim Biophys Acta 2005-12-14

...FPGS) exists as cytosolic and mitochondrial (mFPGS) isoforms. Localization of mFPGS within mitochondria may help elucida...

Kim(Jee Hyun),Lee(Keun-Wook),Jung(Yeonjoo),K… Cancer Sci 2005-08-04

...FPGS) and reduced folate carrier (RFC1) were performed in order to determine whether sensitivity to pemetrexed would be ...

Sohn(K-J),Smirnakis(F),Moskovitz(D N),Novako… Gut 2004-12-14

...FPGS inhibition produced opposite results. FPGS overexpression significantly enhanced, whereas FPGS inhibition decreased...

Ishikawa(Takaaki),Machida(Chiyoko),Yoshioka(… Plant J 2004-01-28

...FPGS) and dihydrofolate synthetase (DHFS), which participate in folate biosynthesis. The defect of gla1 in the formation...

Odin(Elisabeth),Wettergren(Yvonne),Nilsson(S… Clin Cancer Res 2004-07-27

...FPGS levels. The total reduced folate concentration correlated with the gene expression levels of RFC-1 and FPGS but not...

Faessel(Hélène M),Slocum(Harry K),Rustum(You… Int J Oncol 2004-03-04

...FPGS) were individually treated for 96 h with TMQ, AG2034 and a 1:1 mixture of TMQ:AG2034 or with TMQ, RTX, and a 1:1 mi...

Panetta(John Carl),Yanishevski(Yuri),Pui(Chi… Cancer Chemother Pharmacol 2003-01-09

...FPGS (folylpolyglutamate synthetase), and cleavage of glutamyl residues from MTXPG by GGH (gamma-glutamyl hydrolase). Th...

El Fadili(Amal),Kündig(Christoph),Ouellette(… Mol Biochem Parasitol 2003-01-31

...FPGS containing plasmid (FPGS transfectant) exhibited a 6-fold increase in FPGS activity (32.7 pmol mg(-1) h(-1)) compar...

Liani(Esti),Rothem(Lilah),Bunni(Marlene A),S… Int J Cancer 2003-02-06

...FPGS) activity as these cell lines: 1) typically lost 90-99% of parental FPGS activity; 2) expressed 1.4-3.3-fold less F...