Kimme(P),Ledin(T),Sjöberg(F) Acta Physiol Scand 2003-03-06

...FPGs were found only when all values sampled were clustered together, whereas, as a new finding, data are presented indi...

Panetta(John Carl),Yanishevski(Yuri),Pui(Chi… Cancer Chemother Pharmacol 2003-01-09

...FPGS (folylpolyglutamate synthetase), and cleavage of glutamyl residues from MTXPG by GGH (gamma-glutamyl hydrolase). Th...

Gangjee(Aleem),Zeng(Yibin),McGuire(John J),K… J Med Chem 2002-05-10

...FPGS). Further evaluation of the cytotoxicity of 3 in methotrexate-resistant CCRF-CEM cell sublines and metabolite prote...

Andreassi(John L),Moran(Richard G) Biochemistry 2002-01-29

Folylpoly-gamma-glutamate synthetase (FPGS) is the enzyme responsible for metabolic trapping of reduced folate cofactors...

Sheng(Yi),Cross(Jennifer A),Shen(Yang),Smith… Arch Biochem Biophys 2002-07-12

...FPGS) and the structurally equivalent residue, Glu146, in Escherichia coli FPGS. Glu143 is positioned near the P-loop an...

Jackman(Ann L),Melin(Camille J),Kimbell(Rose… Biochim Biophys Acta 2002-08-23

...FPGS) activity. The growth inhibition IC50 values for ZD9331 and raltitrexed were determined for a panel of 18 human tum...

Aburahma(Ali F),Hopkins(Eric S),Wulu(John T)… J Vasc Surg 2002-03-28

...FPGs.,Patients with failed (thrombosed) above-knee FPGs (PTFE, Goretex) during a 10-year period were given the option to...

Gangjee(Aleem),Zeng(Yibin),McGuire(John J),K… J Med Chem 2002-12-09

...FPGS) than MTX. These results show that a classical 5-deaza folate partially restricted via a bridge between the N10 and...

Ravanel(S),Cherest(H),Jabrin(S),Grunwald(D),… Proc Natl Acad Sci U S A 2002-01-22

...FPGS) catalyze the attachment of glutamate residues to the folate molecule. In this study we isolated cDNAs coding a DHF...

Zhao(R),Babani(S),Gao(F),Liu(L),Goldman(I D) Clin Cancer Res 2001-02-01

...FPGS relative to MTX. Cells resistant to MTX because of impaired transport may retain appreciable sensitivity to MTA bec...