Bergman(A M),Giaccone(G),van Moorsel(C J),Ma… Eur J Cancer 2001-01-04

...FPGS) activity and polyglutamation of MTX were found between the cell lines. AG6000 cells were approximately 2 to 7.5-fo...

Rots(M G),Willey(J C),Jansen(G),Van Zantwijk… Leukemia 2001-01-25

...FPGS expression was lower (three-fold, P = 0.006) compared to common/preB-ALL. The ratio of (DHFR x FPGH)/(RFC x FPGS) w...

Lee(C S),Salcedo(E),Wang(Q),Wang(P),Sims(P F… Parasitology 2001-04-12

...FPGS) and serine hydroxymethyltransferase (SHMT). The genes encoding GTP-CH and SHMT are unambiguously assigned to chrom...

Sun(X),Cross(J A),Bognar(A L),Baker(E N),Smi… J Mol Biol 2001-08-23

...FPGS). The reaction mechanism involves the ATP-dependent activation of the free carboxylate group on the folate molecule...

Leclerc(G J),Barredo(J C) Clin Cancer Res 2001-06-14

...FPGS gene in normal or transformed cells in vivo has not been reported. We have examined the mRNA expression of these FP...

Costi(M P),Ferrari(S) Curr Drug Targets 2001-10-18

...FPGS), gamma-glutamyl hydrolase (gamma-GH), glycinamide-ribonucleotide transformylase (GARTfase), amino-imidazole-carbox...

Cole(P D),Kamen(B A),Gorlick(R),Banerjee(D),… Cancer Res 2001-06-21

...FPGS), which adds glutamate residues, and gamma-glutamyl hydrolase (GGH), which removes them. Overexpression of GGH woul...

Salcedo(E),Cortese(J F),Plowe(C V),Sims(P F)… Mol Biochem Parasitol 2001-07-19

...FPGS, indicate that current antifolate regimes do not target this enzyme. As PfDHFS--FPGS harbours two activities critic...

Cavallo(R),Lembo(D),Gribaudo(G),Landolfo(S) Intervirology 2001-10-11

...FPGS mRNAs as well as the enzymatically active FPGS protein through a mechanism that requires viral gene expression. FPG...

Gangjee(A),Zeng(Y),McGuire(J J),Kisliuk(R L) J Med Chem 2000-09-08

...FPGS). These data suggested that FPGS is relatively tolerant to different conformations in the bridge region. Further ev...