...TSC2) mutations were common. One case had FGF10 amplification, whereas another had FGF3-TACC gene fusion, not previously...
...Tsc2 function in tuberous sclerosis complex (TSC) results in altered mammalian target of rapamycin (mTOR) signaling and ...
...TSC2. As for other tumor suppressor gene syndromes, the mechanism of somatic second-hit events in TSC tumors is unknown....
...TSC2) and p70 ribosomal S6 kinase 1 (p70S6K1) phosphorylation, components of the mTOR pathway, which enhances p19(Arf) m...
...TSC2 genes. Although LAM cells are known to express estrogen and progesterone receptors (ER and PR, respectively), their...
...TSC2. These reports highlight the importance of subcellular localization in the regulation of mTORC1.
...TSC2-TBC1D7 complex (the TSC complex) to turn on Rheb, an essential activator of mTORC1. However, the mechanistic basis ...
...TSC2 subcellular localization may be a general mechanism to control its activity and place TSC2 in the amino-acid-sensin...
...Tsc2 heterozygous (+/-) mice, immune system-related pathways, genes encoding ribosomal proteins, and glycolipid metaboli...
...Tsc2/gigas, rasp, and Chd5/Wrb, and several null alleles of the armitage Piwi-pathway gene. Analysis of a newly induced ...
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