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Folate depletion increases sensitivity of solid tumor cell lines to 5-fluoroura…

Backus(H H),Pinedo(H M),Wouters(D),Padrón(J … Int J Cancer 2000-09-07

...FPGS) activity was observed. Furthermore, the protein expression and catalytic activity of the target enzyme TS were up ...

Expression patterns of the multiple transcripts from the folylpolyglutamate syn…

Turner(F B),Taylor(S M),Moran(R G) J Biol Chem 2000-12-29

...FPGS transcripts and found some striking differences to transcription of the mouse gene that allow production of FPGS is...

Tissue-specific expression of functional isoforms of mouse folypoly-gamma-gluta…

Turner(F B),Andreassi 2nd(J L),Ferguson(J),T… Cancer Res 2000-01-24

...FPGS). Using 5'-rapid amplification of cDNA ends, RNase protection assays, transfection of cDNAs into FPGS-deficient cel...

Molecular analysis of murine leukemia cell lines resistant to 5, 10-dideazatetr…

Zhao(R),Titus(S),Gao(F),Moran(R G),Goldman(I… J Biol Chem 2000-09-25

...FPGS) activity was decreased by >98%. In each cell line, FPGS mRNA expression was unchanged but both alleles of the FPGS...

Human cytosolic and mitochondrial folylpolyglutamate synthetase are electrophor…

McGuire(J J),Russell(C A),Balinska(M) J Biol Chem 2000-06-02

...FPGS (hcFPGS) migrated more rapidly than mitochondrial FPGS (hmFPGS); their estimated difference in molecular mass was 1...

Structural and functional similarities in the ADP-forming amide bond ligase sup…

Sheng(Y),Sun(X),Shen(Y),Bognar(A L),Baker(E … J Mol Biol 2000-10-19

Comparison of the three-dimensional structures of folylpolyglutamate synthetase (FPGS) and the bacterial cell wall ligas...

Two promoters regulate transcription of the mouse folylpolyglutamate synthetase…

Chen(J),Hayes(P),Roy(K),Sirotnak(F M) Gene 2000-04-03

...FPGS) in mammalian cells has nutritional and pharmacological importance. In murine cells, FPGS expression is controlled ...

Purification and characteristics of recombinant human folylpoly-gamma-glutamate…

Sanghani(P C),Moran(R G) Protein Expr Purif 2000-03-09

...FPGS) cloned from human leukemic cells in baculovirus-infected insect cells at levels of 4-5% of the total soluble prote...

Marked variation of thymidylate synthase and folylpolyglutamate synthetase gene…

Mini(E),Biondi(C),Morganti(M),Napoli(C),Mazz… Oncol Res 2000-06-30

...FPGS) expression. To establish the value of these genes as prognostic factors and predictors of the outcome of 5-FU-base...

Design and synthesis of Cyclopenta[g]quinazoline-based antifolates as inhibitor…

Bavetsias(V),Marriott(J H),Melin(C),Kimbell(… J Med Chem 2000-06-29

...FPGS) expression and/or an impaired RFC. Examination of a computer graphics model of the humanized Escherichia coli TS e...

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