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The p97/VCP segregase is essential for arsenic-induced degradation of PML and P…

Jaffray(EG),Tatham(MH),Mojsa(B),Liczmanska(M… J Cell Biol 2023-00-03

...RARA) fusion protein. Therapy with arsenic trioxide results in degradation of PML-RARA and PML and cures the disease. Mo...

PML/RARa inhibits PTEN expression in hematopoietic cells by competing with PU.1…

Noguera(Nélida Inés),Piredda(Maria Liliana),… Oncotarget 0000-00-00

...RARA, that acts as a transcriptional repressor impairing the expression of genes that are critical to myeloid differenti...

ATRA resistance conferred by a clustered subset of hotspot PML::RARA mutations …

Barbosa(GM),Yuan(H),Tambones(I),Stote(RH),Wu… Haematologica 2026-08-13

...RARA partners with repressive ability. Similar to ATRA-resistant PLZF::RARA variants, these observations stress the role...

Post-embedding colloidal gold immunolocalization of laminin to the lamina rara …

Abrahamson(DR) J Histochem Cytochem 1986-07-00

...rara externa greater than lamina rara interna. Closely similar binding patterns were found when kidneys were fixed with ...

Emerging Cancer Epigenetic Mechanisms Regulated by All-Trans Retinoic Acid.

Rossetti(S),Sacchi(N) Cancers (Basel) 2020-08-14

...RARA fusion genes as the PML-RARA gene. Over the years, ANXA8 has also been found to be upregulated in other cancers, ev...

[Leukemic cell kinetics of APL with a novel complex variant t (12;17;15)(p13;q2…

Saiki(Y),Sakai(H),Uchida(A),Uemura(Y),Matsun… Rinsho Ketsueki 2020-00-00

...RARA and was treated using all-trans retinoic acid (ATRA). In peripheral blood (PB), PML-RARA-positive polymorphonuclear...

Genomic anatomy of the specific reciprocal translocation t(15;17) in acute prom…

Reiter(A),Saussele(S),Grimwade(D),Wiemels(JL… Genes Chromosomes Cancer 2003-02-00

...RARA intron 2, (ii). amplified and sequenced the genomic PML-RARA junction sequences from 37 APL patients, and (iii). am...

Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors dete…

He(LZ),Guidez(F),Tribioli(C),Peruzzi(D),Ruth… Nat Genet 1998-02-00

...RARA and the PLZF gene do not respond to RA. We have generated PML-RARA and PLZF-RARA transgenic mice and show here that...

Molecular Heterogeneity of Pediatric AML with Atypical Promyelocytes Accumulati…

Borkovskaia(A),Bogacheva(S),Konyukhova(T),Da… Genes (Basel) 2023-00-08

...RARA chimeric gene formation (94.1%). Other RARA-positive cases exhibited cryptic PML::RARA fusion without t(15;17)(q24;...

Eya2, a Target Activated by Plzf, Is Critical for PLZF-RARA-Induced Leukemogene…

Ono(R),Masuya(M),Ishii(S),Katayama(N),Nosaka… Mol Cell Biol 2017-00-01

...RARA, in the aberrant self-renewal. Indeed, PLZF-RARA as well as Plzf rendered those cells immortalized through upregula...

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