...RARA) fusion protein. Therapy with arsenic trioxide results in degradation of PML-RARA and PML and cures the disease. Mo...
...RARA, that acts as a transcriptional repressor impairing the expression of genes that are critical to myeloid differenti...
...RARA partners with repressive ability. Similar to ATRA-resistant PLZF::RARA variants, these observations stress the role...
...rara externa greater than lamina rara interna. Closely similar binding patterns were found when kidneys were fixed with ...
...RARA fusion genes as the PML-RARA gene. Over the years, ANXA8 has also been found to be upregulated in other cancers, ev...
...RARA and was treated using all-trans retinoic acid (ATRA). In peripheral blood (PB), PML-RARA-positive polymorphonuclear...
...RARA intron 2, (ii). amplified and sequenced the genomic PML-RARA junction sequences from 37 APL patients, and (iii). am...
...RARA and the PLZF gene do not respond to RA. We have generated PML-RARA and PLZF-RARA transgenic mice and show here that...
...RARA chimeric gene formation (94.1%). Other RARA-positive cases exhibited cryptic PML::RARA fusion without t(15;17)(q24;...
...RARA, in the aberrant self-renewal. Indeed, PLZF-RARA as well as Plzf rendered those cells immortalized through upregula...
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