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Methotrexate resistance in relation to treatment outcome in childhood acute lym…

Wojtuszkiewicz(Anna),Peters(Godefridus J),va… J Hematol Oncol 2016-03-24

...FPGS, FPGH, RFC, DHFR, and TS), MTX sensitivity as determined by the TS inhibition assay, and FPGS activity.,Herein we d...

Impact of GGCX, STX1B and FPGS Polymorphisms on Warfarin Dose Requirements in E…

Hamadeh(I S),Shahin(M H),Lima(S M),Oliveira(… Clin Transl Sci 2016-11-14

...FPGS, or STX1B are associated with warfarin dose requirements in African-Americans. We sought to determine if they influ...

Association between mRNA expression of chemotherapy-related genes and clinicopa…

Shimamoto(Yuji),Nukatsuka(Mamoru),Takechi(Te… Int J Mol Med 2016-10-27

...FPGS) and gamma-glutamyl hydrolase (GGH); irinotecan-related topoisomerase I (TOP1); oxaliplatin-related excision repair...

Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leuke…

Wojtuszkiewicz(Anna),Raz(Shachar),Stark(Mich… Int J Cancer 2016-06-09

...FPGS) splicing possibly contributes to the loss of FPGS activity in MTX-resistant leukemia cell line models and adult le...

Methotrexate pharmacokinetic genetic variants are associated with outcome in rh…

Moya(Patricia),Salazar(Juliana),Arranz(María… Pharmacogenomics 2016-09-01

...FPGS and GGH genes.,We studied 194 RA patients receiving MTX monotherapy. Two FPGS SNPs, rs10987742 and rs10106, were as...

Mutation Screening and Association Study of the Folylpolyglutamate Synthetase (…

Piwkham(Duangjai),Siriboonpiputtana(Teerapon… Asian Pac J Cancer Prev 2016-04-05

...FPGS gene and the association between single nucleotide polymorphisms (SNPs) within FPGS in a case-control sample of chi...

Effects of folylpolyglutamate synthase modulation on global and gene-specific D…

Kim(Sung-Eun),Hinoue(Toshinori),Kim(Michael … J Nutr Biochem 2016-10-31

...FPGS) plays a critical role in intracellular folate homeostasis. FPGS-induced polyglutamylated folates are better substr...

Preliminary study for predicting better methotrexate efficacy in Japanese patie…

Hashiguchi(Masayuki),Tsuru(Tomomi),Miyawaki(… J Pharm Health Care Sci 2016-06-09

...FPGS 1994G > A, GGH 401C > T, MTHFR 1298A > C, and TYMS 3'-UTR (-6/+6) was performed using the real-time PCR system.,Sev...

Do we need colonoscopy verification in patients with fundic gland polyp?

Lee(Hee Sook),Choi(Younjeong),Jung(Ja Young)… Intest Res 2016-05-13

...FPGs who underwent colonoscopy between January 2009 and December 2013. For each case, age- (±5 years) and sex-matched co...

Determinants of erythrocyte methotrexate polyglutamate levels in rheumatoid art…

den Boer(Ethan),de Rotte(Maurits C J F),Plui… J Rheumatol 2016-01-06

...FPGS) rs4451422 wild-type genotype had higher concentrations of MTX-PG3 (p<0.05), MTX-PG4+5 (p<0.05), and total MTX-PG (...

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