Chazal(M),Cheradame(S),Formento(J L),Francou… Clin Cancer Res 1999-02-18

...FPGS. FPGS activity expressed in liver metastases was significantly correlated to that expressed in primaries. The distr...

Atkinson(I J),Nargang(F E),Cossins(E A) Phytochemistry 1999-02-08

In Neurospora crassa, the met-6+ gene encodes folylpoly-gamma-glutamate synthetase (FPGS) which catalyzes the formation ...

van Triest(B),Pinedo(H M),van Hensbergen(Y),… Clin Cancer Res 1999-06-22

...FPGS) activity showed a range from 47 to 429 pmol/10(6) cells/h. A total of 24 h of [3H]MTX accumulation showed a 20-fol...

Rosowsky(A),Forsch(R A),Null(A),Moran(R G) J Med Chem 1999-10-14

...FPGS, whereas 1 and 2 were exceptionally efficient FPGS substrates, with the reduced compound 2 giving a K(m) (0.018 mic...

Barnes(M J),Estlin(E J),Taylor(G A),Aherne(G… Clin Cancer Res 1999-11-22

The aim of this study was to investigate the influence of folylpolyglutamyl synthetase (FPGS) activity on the cellular p...

Gorlick(R),Cole(P),Banerjee(D),Longo(G),Li(W… Adv Exp Med Biol 1999-11-04

...FPGS) were studied, demonstrating FPGS in the myeloid cell lines and patient samples had a higher K(m) for MTX as a subs...

Takemura(Y),Kobayashi(H),Miyachi(H) Anticancer Drugs 1999-10-28

We investigated the expression of the folylpolyglutamate synthetase (FPGS) gene at the mRNA level in MOLT-3 and K562 hum...

Sanghani(S P),Sanghani(P C),Moran(R G) J Biol Chem 1999-10-13

...FPGS activity, one mutant (D335A) did not complement the auxotrophy, and another (R377A) allowed only minimal growth. FP...

Moran(R G) Semin Oncol 1999-12-21

Folylpoly-gamma-glutamate synthetase (FPGS) catalyzes the addition of several equivalents of glutamic acid to the gamma-...

Mendelsohn(L G),Shih(C),Chen(V J),Habeck(L L… Semin Oncol 1999-12-21

...FPGS) activated MTA very efficiently. Using FPGS from two different species, Km values below 2 micromol/L and high relat...