...RARA knock-in mouse model of APL (Ctsg-PML-RARA). We identified a Notch expression signature in both human primary APL c...
...RARA-driven APL, but not the RA-resistant promyelocytic leukemia zinc finger (PLZF)-RARA variant. Yet, as NB biogenesis ...
...RARA fusion. However, a small subset of patients harbor cryptic or atypical RARA rearrangements that escape detection by...
...rAra h 6-E. coli and rAra h 6-Pichia, respectively). Effector activity was assayed by measuring degranulation of RBL SX-...
...RARA and STAT5b-RARA. Despite their rarity (<1% of APL) we identified 6 cases (PLZF-RARA, n = 5; STAT5b-RARA, n = 1), es...
...rara interna, lamina densa, lamina rara externa and the glomerular epithelial cell was determined by electron microscopi...
...RARA is the primary abnormality implicated in this pathology, but the mechanisms by which this chimeric fusion protein i...
...RARA dual-color DNA probe. FISH showed a PML-RARA fusion gene on the der(12) instead of the der(15). The patient was tre...
...RARA agonist, has been reported to partially overcome this resistance in AML with high RARA expression. However, its eff...
...RARA fusion partners, such as FIP1L1-RARA, are typically resistant to ATRA/ATO-based regimens and are associated with po...
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