Aghi(M),Kramm(C M),Breakefield(X O) J Natl Cancer Inst 1999-08-19

...FPGS activity, and in canine and human glioblastoma cell lines transduced with a vector bearing FPGS cDNA.,FPGS gene del...

Chéradame(S),Chazal(M),Fischel(J L),Formento… Anticancer Drugs 1999-09-30

...FPGS activity and TX IC50r = -0.56, p = 0.03. Tumor cells with a relatively high FPGS activity were more sensitive to TX...

Rosowsky(A),Forsch(R A),Null(A),Moran(R G) J Med Chem 1999-10-14

...FPGS, whereas 1 and 2 were exceptionally efficient FPGS substrates, with the reduced compound 2 giving a K(m) (0.018 mic...

Qi(H),Atkinson(I),Xiao(S),Choi(Y J),Tobimats… Adv Enzyme Regul 1999-10-22

...FPGS. Three additional human FPGS mRNAs differing in exon 1 have been identified. One of these is a major species in HEP...

Sanghani(S P),Sanghani(P C),Moran(R G) J Biol Chem 1999-10-13

...FPGS activity, one mutant (D335A) did not complement the auxotrophy, and another (R377A) allowed only minimal growth. FP...

Liu(Y),Raghunathan(K),Hill(C),He(Y),Bunni(M … Biochem Pharmacol 1998-09-14

...FPGS activity. This inducible expression system was used to demonstrate that lower FPGS activity can lead to substantial...

Tsukamoto(T),Haile(W H),McGuire(J J),Coward(… Arch Biochem Biophys 1998-07-20

Folylpolyglutamate synthetase (FPGS) catalyzes anATP-dependent ligation reaction that results in the synthesis of poly(g...

Kobayashi(H),Takemura(Y),Miyachi(H) Cancer Chemother Pharmacol 1998-07-09

...FPGS) in a human acute lymphoblastic leukemia cell line, MOLT-3, made resistant to ZD9331. A 310-fold resistant subline ...

Bavetsias(V),Jackman(A L) Curr Med Chem 1998-10-27

...FPGS). Lipophilic inhibitors of the enzyme were expected not to depend on the reduced folate carrier transporter (RFC) f...

Walton(M I),Mitchell(F),Aherne(G W),Medlow(C… Br J Cancer 1998-12-07

...FPGS) for its activity. In contrast to Tomudex (ZD1694), ZD9331 may therefore be active against tumours with low FPGS ac...