Takemura(Y),Kobayashi(H),Miyachi(H) Int J Hematol 1998-03-17

...FPGS). Tumor cells may develop resistance to an antifolate drug by virtue of, (1) amplified activity in its target enzym...

Odin(E),Larsson(L),Aram(M),Gustavsson(B),Lar… Tumour Biol 1998-05-27

...FPGS) and thymidylate synthase (TS), using beta-actin as an internal standard (house-keeping gene). Total RNA was isolat...

McGuire(J J),Russell(C A) Oncol Res 1998-12-11

...FPGS) is often essential to their cytotoxic activity. FPGS expression in the MTX-sensitive human T-lymphoblastic leukemi...

Synold(T W),Willits(E M),Barredo(J C) Leuk Lymphoma 1997-03-25

...FPGS) as an important metabolic step in the "activation" of classical antifolates and novel drugs aimed at thymidylate s...

McGuire(J J),Haile(W H),Russell(C A),Galvin(… Oncol Res 1997-02-19

...FPGS gene copy number or restriction pattern, or FPGS mRNA level or size (2.3 Kb) was detected in populations. Decreased...

Jackman(A L),Boyle(F T),Harrap(K R) Invest New Drugs 1997-04-14

...FPGS). This paper reviews the underlying philosophies, and the milestones reached during the development of Tomudex.

McGuire(J J),Tsukamoto(T),Hart(B P),Coward(J… Invest New Drugs 1997-04-14

...FPGS), are poorly transported, apparently because of interference by the protonated delta-amine. Replacement of Orn with...

Matsuoka(H),Maruyama(N),Suzuki(H),Kuroki(T),… Chem Pharm Bull (Tokyo) 1997-03-04

...FPGS), and thus did not undergo polyglutamation, which is thought to be responsible for side-effects that occur during M...

Roy(K),Mitsugi(K),Sirotnak(F M) J Biol Chem 1997-04-15

...FPGS RNA transcripts incorporating exons B1a, B1b, and B1c were detected mainly in tumors. Thus, transcription of the FP...

Galpin(A J),Schuetz(J D),Masson(E),Yanishevs… Mol Pharmacol 1997-08-08

...FPGS mRNA and enzyme activity in lymphoblasts from children with newly diagnosed ALL, and blast FPGS mRNA and activity i...