Freemantle(S J),Moran(R G) J Biol Chem 1997-10-22

...FPGS promoter controlling transcription of the FPGS gene in human CEM leukemia cells, a line which expresses high levels...

Longo(G S),Gorlick(R),Tong(W P),Lin(S),Stein… Oncol Res 1997-10-23

...FPGS), which adds glutamates to MTX in a gamma-carboxyl linkage, and gamma-glutamyl hydrolase (GGH) or conjugase, which ...

Chéradame(S),Etienne(M C),Chazal(M),Guillot(… Eur J Cancer 1997-09-24

...FPGS activity (range 2.5-11.1 pmol/min/mg protein): the higher the FPGS activity, the greater the 5-FU sensitivity. Unde...

Dolnick(B J),Lu(K),Yin(M B),Rustum(Y M) Adv Enzyme Regul 1997-11-10

...FPGS activity, the possibility that rTS may affect folate binding remains a hypothesis worth examining. The recent disco...

Roy(K),Egan(M G),Sirlin(S),Sirotnak(F M) J Biol Chem 1997-04-17

...FPGS) activity compared with parental L1210 cells. Lower levels of FPGS activity in cell-free extract from these variant...

Takemura(Y),Jackman(A L) Anticancer Drugs 1997-05-15

...FPGS), has enabled the rational design and development of the selective thymidylate synthase (TS) inhibitors with folate...

Jackman(A L),Kimbell(R),Brown(M),Brunton(L),… Anticancer Drug Des 1996-01-16

...FPGS) and the reduced-folate cell membrane carrier (RFC). Short-exposure growth-inhibition assays or the measurement of ...

van der Wilt(C L),Cloos(J),de Jong(M),Pinedo… Oncol Res 1996-02-01

Polyglutamylation of (anti)folates catalyzed by folylpolyglutamate synthetase (FPGS) determines the retention of these c...

Jackman(A L),Calvert(A H) Ann Oncol 1996-06-26

...FPGS). An example of a compound that uses both of these processes well is the quinazoline, ZD1694 (Tomudex), a drug whic...

Fussenegger(M),Meyer(T F) Mol Gen Genet 1996-05-06

...FPGS-DHFS and 29% identity to the FPGS of Lacto-bacillus casei. Sequence comparisons between the three genes reveal regi...