Fussenegger(M),Meyer(T F) Mol Gen Genet 1996-05-06

...FPGS-DHFS and 29% identity to the FPGS of Lacto-bacillus casei. Sequence comparisons between the three genes reveal regi...

Mao(Z),Pan(J),Kalman(T I) J Med Chem 1996-11-25

Folypolyglutamate synthetase (FPGS) is responsible for the conversion of naturally occurring folates and antifolates to ...

Tsukamoto(T),Kitazume(T),McGuire(J J),Coward… J Med Chem 1996-03-01

...FPGS), revealed that DL-4,4-F2Glu is a poor alternate substrate. DL-gamma,gamma-F2MTX was synthesized by a route proceed...

Drake(J C),Allegra(C J),Moran(R G),Johnston(… Biochem Pharmacol 1996-09-20

...FPGS) activity was 48-fold less compared to parent H630 cells; however, FPGS mRNA expression was similar in both lines. ...

Hanlon(M H),Ferone(R) Cancer Res 1996-09-20

...FPGS. This correlation between substrate efficiency for FPGS and cytotoxicity suggests that polyglutamation of 1843U89 c...

Etienne(M C),Guillot(T),Milano(G) Ann Oncol 1996-11-05

...FPGS), the enzyme responsible for folate polyglutamylation, is another promising tool for identifying FU-FA-responsive t...

Tsukamoto(T),Haile(W H),McGuire(J J),Coward(… J Med Chem 1996-08-23

...FPGS), dihydrofolate reductase (DHFR), and cell growth. Synthesis of 4 involved the use of a protected form of DL-4,4-di...

Mendelsohn(L G),Gates(S B),Habeck(L L),Shack… Adv Enzyme Regul 1996-12-30

...FPGS activity increased in several tumors and liver and kidney of LFD mice. The increase in this enzyme activity would r...

McGuire(J J),Haile(W H) Arch Biochem Biophys 1996-12-24

...FPGS), a crucial enzyme in folate metabolism. Suramin is a more potent (IC50, 0.9 microM) inhibitor of FPGS partially pu...

Gates(S B),Worzalla(J F),Shih(C),Grindey(G B… Biochem Pharmacol 1996-12-31

...FPGS) activity. Activities were measured using lometrexol (6R-5,10-dideazatetrahydrofolic acid) as a substrate for FPGS ...