Pendergast(W),Dickerson(S H),Dev(I K),Ferone… J Med Chem 1994-05-04

...FPGS substrate activity, and affinity for the reduced folate transport system in the most potent of these derivatives, 3...

Lin(B F),Shane(B) J Biol Chem 1994-05-05

...FPGS to the mitochondria of these cells. Mitochondrial expression of FPGS restored mitochondrial folylpolyglutamate pool...

Kim(J S),Shane(B) J Biol Chem 1994-05-05

...FPGS activity. After short term exposure to DATHF, cells expressing higher levels of human FPGS were more sensitive to t...

Itoh(F),Russello(O),Akimoto(H),Beardsley(G P) Cancer Chemother Pharmacol 1994-08-15

...FPGS), aminoimidazolecarboxamide ribonucleotide transformylase (AICARTFase), and glycinamide ribonucleotide transformyla...

McGuire(J J),Heitzman(K J),Haile(W H),Russel… Leukemia 1994-01-07

...FPGS level was noted to the lipid-soluble antifolate trimetrexate and to 5,8-dideazapteroyl-L-ornithine, an FPGS-specifi...

Jackman(A L),Bisset(G M),Jodrell(D I),Gibson… Adv Exp Med Biol 1994-03-10

...FPGS, led us to the synthesis of dipeptide analogues of ICI 198583 diglutamate. Although a number of dipeptide analogues...

Jackman(A L),Gibson(W),Brown(M),Kimbell(R),B… Adv Exp Med Biol 1994-06-07

...FPGS. For example, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolate (ICI 198583) owes its less potent cytotoxic activ...

Barredo(J C),Synold(T W),Laver(J),Relling(M … Blood 1994-08-11

...FPGS expression, FPGS activity increased in ALL blasts after in vivo exposure to MTX. The median increase in FPGS activi...

Osborne(C B),Lowe(K E),Shane(B) J Biol Chem 1993-11-18

...FPGS activity and lacking folylpolyglutamates. Only low levels of FPGS are required to enable cellular metabolism of fol...

Lowe(K E),Osborne(C B),Lin(B F),Kim(J S),Hsu… J Biol Chem 1993-11-18

...FPGS activity. At low medium folate concentrations, folate accumulation was limited by influx and was independent of FPG...