...TSC2 trigger mammalian cell size reduction and a dominant-negative TSC2 mutant induces increased size. These effects occ...
...TSC2. We found expression of PCNA and the p48 subunit of CAF-1 to be regulated by two tuberous sclerosis gene products. ...
...Tsc2/Nth1 promoters. Elf-1 may be a negative regulator of Tsc2/Nth1 gene expression and may compete against positive reg...
...TSC2, that encode hamartin and tuberin, respectively. Interaction of hamartin with tuberin forms a heterodimer that inhi...
...Tsc2) gene. Pkdl was found ubiquitously expressed in the normal rat tissues and the brain had a complex pattern of exon ...
...TSC2 genes give rise to the clinical disorder of tuberous sclerosis characterized by the development of hamartomas predo...
...TSC2. 75% of cases are sporadic. Most patients with TS have epilepsy. Infantile spasms are a frequent early manifestatio...
...TSC2 tumor suppressor genes, are closely related to their direct interactions. However, the regulation of the hamartin-t...
...TSC2 tumour suppressor gene is responsible for both the familial and sporadic forms of this disease. TSC1 and TSC2 prote...
...Tsc2) tumour suppressor and inhibiting formation of a Tsc1-Tsc2 complex. We show that Akt/PKB directly phosphorylates Dr...
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