Lin(B F),Huang(R F),Shane(B) J Biol Chem 1993-11-18

...FPGS) activity contain mitochondrial FPGS activity of higher specific activity than the cytosolic isozyme. Expression of...

Kim(J S),Lowe(K E),Shane(B) J Biol Chem 1993-11-18

...FPGS activity. After short term exposure to MTX, cells expressing higher levels of FPGS were more sensitive to the drug....

Fort(D W),Lark(R H),Smith(A K),Marling-Cason… Br J Haematol 1993-12-21

...FPGS) activity and did not express significant amounts of FPGS mRNA. After 48 h of mitogen stimulation there was a 4-10-...

Rosowsky(A),Forsch(R A),Reich(V E),Freisheim… J Med Chem 1992-06-09

...FPGS) as probes of the FPGS active site and as potential therapeutic agents. The tetrahydro compounds were also of inter...

Shih(C),Gossett(L S),Worzalla(J F),Rinzel(S … J Med Chem 1992-04-28

...FPGS) compared with their bicyclic counterparts. Moderate antitumor activity was observed for compound 2 against 6C3HED ...

Cody(V),Luft(J R),Pangborn(W),Toy(J),Bognar(… J Mol Biol 1992-05-28

Folylpolyglutamate synthetase (FPGS) from Lactobacillus casei has been crystallized with polyethylene glycol and acetate...

van der Laan(B F),Jansen(G),Kathmann(I),Scho… Eur J Cancer 1992-01-09

...FPGS) activity (2.5-fold and 3.8-fold, respectively). Against two novel antifolates targetting enzymes other than DHFR, ...

van der Laan(B F),Jansen(G),Kathmann(G A),We… Int J Cancer 1992-08-31

...FPGS) activity compared to MTX-sensitive HNSCC cells. The 3 cell lines exhibiting inherent resistance to a short exposur...

Garrow(T A),Admon(A),Shane(B) Proc Natl Acad Sci U S A 1992-11-10

...FPGS and shows limited homology to the E. coli and Lactobacillus casei FPGSs. Expression of the cDNA in E. coli results ...

Barredo(J),Moran(R G) Mol Pharmacol 1992-12-01

...FPGS were found in circulating lymphoblasts from eight patients with acute lymphoblastic leukemia. The levels of FPGS fo...